Natural sources, biosynthesis, biological functions, and molecular mechanisms of shikimic acid and its derivatives

查看全文 作　　者：Gopalsamy Rajiv [1]Gandhi;Alan Bruno Silva [2]Vasconcelos;Poovathumkal James [3]Antony;Monalisa Martins [4]Montalvão;Mariana Nobre Farias de [4]Franca;Varghese Edwin [1]Hillary;Stanislaus Antony [5]Ceasar;Dan [6]Liu 机构地区：[1]Division of Phytochemistry and Drug Design,Department of Biosciences,Rajagiri College of Social Sciences,Kalamaserry,Kochi 683104,India;[2]Laboratory of Biology and Immunology of Cancer and Leishmania,Department of Morphology,Federal University of Sergipe,São Cristóvão 49100.000,Sergipe,Brazil;[3]Nepal Jesuit Society,Human Resource Development and Research Centre,Kathmandu 44600,Nepal;[4]Postgraduate Program of Health Sciences,Federal University of Sergipe,Campus Prof.João Cardoso Nascimento,Aracaju 49060.108,Sergipe,Brazil;[5]Division of Plant Molecular Biology and Biotechnology,Department of Biosciences,Rajagiri College of Social Sciences,Kalamaserry,Kochi 683104,India;[6]School of Food and Biological Engineering,Chengdu University,Chengdu 610106,China 出　　处：《Asian Pacific Journal of Tropical Biomedicine》索引2023年第13卷第4期,共9页 基　　金：financial support from Rajagiri College of Social Sciences (Autonomous);Kochi;India;in the seed money category for minor faculty research projects 摘　　要：Shikimic acid is a hydroaromatic compound possessing critical biological properties,such as antibacterial and antiviral activity.This review mainly focused on shikimic acid and its derivatives.We first briefly introduced the sources of shikimic acid and its derivatives and discussed their biosynthesis.Several in vitro and in vivo studies indicate that shikimic acid and its derivatives exhibit diverse bioactivities,such as antioxidant,antiviral,anti-inflammatory,antibacterial,hypolipidemic,bone protective,skin protective,neuroprotective,and antidiabetic activities.We mainly focused on the related molecular mechanisms.Overall,the wide range of bioactivities of shikimic acid and its derivatives indicate that a more detailed exploration of their potential for the prevention and treatment of certain diseases is warranted. 关 键 词：Natural products SHIKIMATE Ginkgo biloba NEUROPROTECTION INFLAMMATION