维普中文期刊产品整合服务

3D magnetic field guided sunflower-like nanocatalytic active swarm targeting patients-derived organoids

查看全文 作　　者：Dong [1,2]Liu;Ruirui [1,2]Guo;Shuangshuang [3]Mao;Yanjie [1,2]Huang;Bin [1]Wang;Zijian [1]Wu;Xuanjie [1]Xia;Jian [2]Dong;Yu [4]Xin;Ruiyang [5]Xie;Jianzhong [5]Shou;Wei [6]Sun;Yuan [3]Pang;Yuan [1]Lu 高影响力作者 机构地区：[1]Key Laboratory of Industrial Biocatalysis,Ministry of Education,Department of Chemical Engineering,Tsinghua University,Beijing 100084,China;[2]Tianjin Industrial Microbiology Key Laboratory,College of Biotechnology,Tianjin University of Science and Technology,Tianjin 300457,China;[3]Biomanufacturing Center,Department of Mechanical Engineering,Tsinghua University,Beijing 100084,China;[4]Department of Neurosurgery,Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China;[5]National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China;[6]Biomanufacturing Center,Dept.of Mechanical Engineering,Tsinghua University,Beijing 100084,China高影响力机构 出　　处：《Nano Research》索引2023年第16卷第1期,共12页高影响力期刊 基　　金：This work was supported by the National Key R&D Program of China(No.2018YFA0901700);the National Natural Science Foundation of China(Nos.21878173,52175273,and 82072837);the 111 Project(No.B17026);a grant from the Institute Guo Qiang,Tsinghua University(No.2021GQG1016). 摘　　要：Nanocatalytic medicine triggering in situ catalytic reactions has been considered as a promising strategy for tumor-selective therapeutics.However,the targeted distribution of nanocatalysts was still low,considering the absence of targeting propulsion capability.Here,encouraged by the fast-developing controllable microrobotics for targeting delivery,a sunflower-like nanocatalytic active swarm(SNCAS)controlled by a three-dimensional(3D)magnetic field was proposed for synergistic tumorselective and magnetic-actively tumor-targeting therapeutics.Furthermore,a patient-derived renal cancer cell 3D organoid was utilized for the verification of the effective tumor therapeutic outcomes.Under the targeted control of 3D magnetic field,the multiple cascade catalytic efficiency of SNCAS based on Fenton reaction was evaluated,resulting in efficient tumor cell apoptosis and death.For the patient-derived organoid treatment,the SNCAS presented significant lethality toward 3D organoid structure to induce cell apoptosis with the collapse of organoid morphology.The targeting efficiency was further enhanced under the magnetic-controllable of SNCAS.Overall,empowered by the magnetic control technology,the synergistic therapeutic strategy based on controllable swarm combined active targeting and tumor-specific catalytic nanomedicine has provided a novel way for advanced cancer therapy.Meanwhile,3D patient-derived organoids were proved as a powerful tool for the effectiveness verification of nanocatalytic medicine. 关 键 词：nanocatalytic swarm magnetic control patients-derived organoids
相关文献

参考文献(41)

引证文献(1)

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费