Protective mechanism of quercetin compounds against acrylamide-induced hepatotoxicity

查看全文 作　　者：Linzi [1]Li;Xueying [1]Lei;Lin [1]Chen;Ya [1]Ma;Jun [2]Luo;Xuebo [1]Liu;Xinglian [3]Xu;Guanghong [3]Zhou;Xianchao [1]Feng

机构地区：[1]College of Food Science and Engineering,Northwest A&F University,Yangling 712100,China;[2]College of Animal Science and Technology,Northwest A&F University,Yangling 712100,China;[3]Synergetic Innovation Center of Food Safety and Nutrition,Key Laboratory of Meat Processing and Quality Control,Ministry of Education,College of Food Science and Technology,Nanjing Agricultural University,Nanjing 210095,China

出　　处：《Food Science and Human Wellness》索引2024年第13卷第1期,共16页

基　　金：supported by the National Natural Science Foundation of China(32072142,31972099);Guangxi Science and Technology Base and Talent Special Projects(Guike AD21220004)。 摘　　要：Quercetin compounds have antioxidant,anti-inflammatory and anticancer pharmacological functions.Longterm exposure to acrylamide(AA)can cause liver injury and endanger human health.However,whether quercetin compounds can attenuate AA-induced liver injury and the specific mechanism are not clear.Here,we studied the mechanism and structure-activity relationship of quercetin compounds in reducing AA-induced hepatotoxicity in vivo and in vitro.In vivo studies found that quercetin-like compounds protect against AAinduced liver injury by reducing oxidative stress levels,activating the Akt/m TOR signaling pathway to attenuate autophagy,and improving mitochondrial apoptosis and endoplasmic reticulum stress-mediated apoptosis.In vitro studies found that quercetin compounds protected Hep G2 cells from AA by attenuating the activation of AA-induced autophagy,lowering reactive oxygen species(ROS)levels by exerting antioxidant effects and thus attenuating oxidative stress,increasing mitochondrial membrane potential(MMP),and improving apoptosis-related proteins,thus attenuating AA-induced apoptosis.Furthermore,the conformational differences between quercetin compounds correlated with their protective capacity against AA-induced hepatotoxicity,with quercetin showing the best protective capacity due to its strongest antioxidant activity.In conclusion,quercetin compounds can protect against AA-induced liver injury through multiple pathways of oxidative stress,autophagy and apoptosis,and their protective capacity correlates with antioxidant activity. 关键词：Quercetin compounds ACRYLAMIDE Protection mechanism Oxidative stress Antioxidant activity

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Protective mechanism of quercetin compounds against acrylamide-induced hepatotoxicity

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