Nanotandem-rocket releases messenger to disrupt metabolic communication for antitumor immunotherapy

查看全文 作　　者：Henan [1]Zhao;Yuyan [1]Zou;Wei [1]Wang;Yihong [1]Liu;Yuqing [1]Li;Bowen [1]Jin;Jianghua [1]Li;Wansong [1]Chen;You-Nian [1]Liu

机构地区：[1]Hunan Provincial Key Laboratory of Micro&Nano Materials Interface Science,College of Chemistry and Chemical Engineering,Central South University,Changsha 410083,China

出　　处：《Nano Research》索引2023年第16卷第5期,共13页

基　　金：the National Natural Science Foundation of China(No.21807117);Hunan Provincial Science and Technology Plan Project(No.2019TP1001);Hunan Provincial Natural Science Foundation of China(Nos.2022JJ20052 and 2021JJ30788);Central South University Innovation-Driven Research Programme(No.2023CXQD021)。 摘　　要：Metabolic communication between intracellular metabolism and extracellular microenvironment is responsible for celluar metabolism balance and cell survival.Tumor cells adaptively regulate metabolic communication to promote hyperproliferation and immunosuppression.Herein,nanotandem-rockets(hyaluronic acid modified Mg_(5)(CO_(3))_(4)(OH)_(2)(H-MCH))are developed for stepwisely disrupting metabolic communication to activate antitumor immunity.Benefiting from the nanotandem-rocket structure,H-MCH nanoplates successively disrupt the extracellular metabolite transport and intracellular carbohydrate metabolism.Theoretical simulation together with metabolomic analysis discloses the underlying mechanism of H-MCH nanotandem-rockets.The extra-/intra-celluar interruption of metabolic communication provides H-MCH nanotandem-rockets with high efficiency in tumor eradication.Moreover,the interference of metabolic communication reverses immunosuppression to facilitate the intratumoral infiltration of immune cells.With H-MCH nanotandem-rockets as an in situ vaccine,systemic antitumor immunity and immune memory effect are fabricated to eliminate tumor metastasis and recurrence.Different from traditional metabolic poisons(e.g.,arsenic or cyanide),the structure of nanotandem-rockets endows chemical messengers with selective regulation to tumor metabolic communication,but with minimal influence to normal tissues.The nanotandem-rockets provide a powerful paltform to augment the regulating actitiy of chemical messengers in metabolic communication.We expect our discovery of disrupting tumor metabolic communication with chemical messengers will be a powerful strategy for tumor therapy with vast practical applications. 关键词：nanotandem-rockets metabolic communication MESSENGER carbohydrate metabolism antitumor immunotherapy

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Nanotandem-rocket releases messenger to disrupt metabolic communication for antitumor immunotherapy

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