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The promise of precision medicine:how biomarkers are shaping the future of cholangiocarcinoma treatment

查看全文 作　　者：Rocio [1,2]I.R.Macias;Lorenza [3,4]Rimassa;Angela [5,6,7]Lamarca 高影响力作者 机构地区：[1]Experimental Hepatology and Drug Targeting(HEVEPHARM),IBSAL,University of Salamanca,Salamanca,Spain;[2]National Institute for the Study of Liver and Gastrointestinal Diseases(CIBERehd),Carlos III National Health Institute,Madrid,Spain;[3]Department of Biomedical Sciences,Humanitas University,Pieve Emanuele(Milan),Italy;[4]Medical Oncology and Hematology Unit,Humanitas Cancer Center,IRCCS Humanitas Research Hospital,Rozzano(Milan),Italy;[5]Department of Oncology,OncoHealth Institute,Fundación Jiménez Díaz University Hospital,Madrid,Spain;[6]Department of Medical Oncology,The Christie NHS Foundation,Manchester,UK;[7]Division of Cancer Sciences,University of Manchester,Manchester,UK高影响力机构 出　　处：《Hepatobiliary Surgery and Nutrition》索引2023年第12卷第3期,共5页高影响力期刊 摘　　要：Cholangiocarcinoma(CCA)is the second most frequent primary malignant neoplasm of the hepatobiliary system.Unfortunately,CCA is often diagnosed at an advanced stage,when potentially curative surgical treatments are not recommended.The probability of achieving complete resection in patients who undergo surgery is about 25%(1)and even when complete tumor removal is achieved,the risk of recurrence is greater than 50%.Identification and validation of reliable biomarkers is crucial for the early detection,accurate diagnosis,appropriate staging/prognosis,therapy selection and effective monitoring of patients with biliary tract cancers(BTCs)(Figure 1).Achieving early diagnosis remains a challenge to improve survival and,although many promising biomarkers have been identified(2),to date none have reached clinical practice. 关 键 词：Biliary cancer BIOMARKER IMMUNOTHERAPY precision medicine targeted therapy
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