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Using machine learning to identify factors related to nitrous oxide(laughing gas)relapse among adolescents

查看全文 作　　者：Jie [1,2,3]Xu;Yi [4]Zhang;Chang [5,6]Lei;Pei [2]Sun;Runsen [5,6]Chen;Tifei [4,7]Yuan 高影响力作者 机构地区：[1]Beijing Gaoxin Hospital,Beijing,China;[2]Department of Psychology,Tsinghua University,Beijing,China;[3]Department of Psychiatry and Psychology,Tianjin Medical University,Tianjin,China;[4]Shanghai Key Laboratory of Psychotic Disorders,Brain Health Institute,National Center for Mental Disorders,Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai,China;[5]Vanke School of Public Health,Tsinghua University,Beijing,China;[6]Institute for Healthy China,Tsinghua University,Beijing,China;[7]Co-innovation Center of Neuroregeneration,Nantong University,Nantong,Jiangsu,China高影响力机构 出　　处：《General Psychiatry》索引2023年第36卷第2期,共5页高影响力期刊 基　　金：National Natural Science Foundation of China grant(32241015,81822017);the Lingang Laboratory(LG-QS-202203-10);the Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support(20181715);the Shanghai Municipal Commission of Health(2022JC016). 摘　　要：Introduction Nitrous oxide(N2O/laughing gas)has been used in medical practice as an inhalational anaesthetic and analgesic for more than 150 years.1 In the past decades,N2O exhibited increasing popularity among recreational drug users for its euphoric effects,potentially through its interaction with the endogenous opioid system.2 Recreational use of N2O emerged as the seventh most used drug globally in the past decade.3 The use of N2O can cause myelopathy,myocardial injury,anaemia,severe mood disorders,sensory and motor neuropathy,and psychotic symptoms.45 Prolonged N2O intake results in vitamin B12 deficiency and inhibits methionine synthetase,folate and DNA production,leading to plasma homocysteine(HCY)level elevation and bone marrow haematopoietic dysfunction.6 This study aimed to investigate the neurological symptoms of nitrous oxide use and then explore the relapse trajectory and risk factors for relapse. 关 键 词：RELAPSE VITAMIN ENDOGENOUS
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