维普中文期刊产品整合服务

Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma

查看全文 作　　者：Yubing [1,2]Zhou;Xinyu [1,2]He;Yanan [1,2,3,4]Jiang;Zitong [1]Wang;Yin [1,2]Yu;Wenjie [1,2]Wu;Chenyang [1]Zhang;Jincheng [1]Li;Yaping [1,3]Guo;Xinhuan [1,3]Chen;Zhicai [4,6]Liu;Jimin [1,3,4,5]Zhao;Kangdong [1,2,3,4,5]Liu;Zigang [1,2,3,5]Dong 高影响力作者 机构地区：[1]The Pathophysiology Department,School of Basic Medical Sciences,Academy of Medical Sciences,Zhengzhou University,Zhengzhou 450000,China;[2]The China-US(Henan)Hormel Cancer Institute,Zhengzhou 450000,China;[3]State Key Laboratory of Esophageal Cancer Prevention and Treatment,Zhengzhou 450000,China;[4]Provincial Cooperative Innovation Center for Cancer Chemoprevention,Zhengzhou University,Zhengzhou 450000,China;[5]Cancer Chemoprevention International Collaboration Laboratory,Zhengzhou 450000,China;[6]Oncology Department,The Tumor Hospital of Linzhou City,Linzhou 456500,China高影响力机构 出　　处：《Frontiers of Medicine》索引2023年第17卷第2期,共14页高影响力期刊 基　　金：supported by the National Natural Science Foundations of China(No.81872335);the National Natural Science Youth Foundation(No.81902486);the Natural Science Foundation of Henan(No.161100510300);the Central Plains Science and Technology Innovation Leading Talents(No.224200510015);the Science and Technology Project of Henan Province(No.212102310187). 摘　　要：Esophageal squamous cell carcinoma (ESCC) is one of the leading causes of cancer death worldwide. It is urgent to develop new drugs to improve the prognosis of ESCC patients. Here, we found benzydamine, a locally acting non-steroidal anti-inflammatory drug, had potent cytotoxic effect on ESCC cells. Benzydamine could suppress ESCC proliferation in vivo and in vitro. In terms of mechanism, CDK2 was identified as a target of benzydamine by molecular docking, pull-down assay and in vitro kinase assay. Specifically, benzydamine inhibited the growth of ESCC cells by inhibiting CDK2 activity and affecting downstream phosphorylation of MCM2, c-Myc and Rb, resulting in cell cycle arrest. Our study illustrates that benzydamine inhibits the growth of ESCC cells by downregulating the CDK2 pathway. 关 键 词：benzydamine cyclin-dependent kinase 2 patient-derived xenograft esophageal squamous cell carcinoma
相关文献

参考文献(41)

引证文献(1)

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费