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Clinical characteristics and survival analysis of colorectal cancer in China:a retrospective cohort study with 13,328 patients from southern China

查看全文 作　　者：Lekun [1,2,3]Fang;Ziqing [1,2]Yang;Mingliang [4]Zhang;Manqi [1,2]Meng;Junyan [1,2]Feng;Chuangqi [4]Chen 高影响力作者 机构地区：[1]Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease,The Sixth Affiliated Hospital of Sun Yat-sen University,Guangzhou,Guangdong,P.R.China;[2]Guangdong Research Institute of Gastroenterology,The Sixth Affiliated Hospital of Sun Yat-sen University,Guangzhou,Guangdong,P.R.China;[3]Department of Colorectal Surgery,The Sixth Affiliated Hospital of Sun Yat-sen University,Guangzhou,Guangdong,P.R.China;[4]Department of Colorectal Surgery,The First Affiliated Hospital of Sun Yat-sen University,Guangzhou,Guangdong,P.R.China高影响力机构 出　　处：《Gastroenterology Report》索引2021年第9卷第6期,共12页高影响力期刊 基　　金：supported by the National Natural Science Foundation of China[81773098,82111530099];Guangdong Special Young Talent Plan of Scientific and Technological Innovation[2019TQ05Y510];the Guangdong International Joint Research Program[2020A0505100027];Nature Science Foundation of Guangzhou[202102080387];Guangdong Public Health Project[2021-58]and National Key Clinical Discipline. 摘　　要：Background:Colorectal cancer(CRC)is one of the most common cancers in China.However,detailed clinical characteristics and survival information are limited.This study aimed to investigate the potential epidemiological and clinical risk factors affecting the survival of CRC patients in southern China.Methods:Patients with primary CRC between 1994 and 2019 at the First and the Sixth Affiliated Hospitals of Sun Yat-sen University(Guangzhou,China)were included.Clinical characteristics and survival outcomes were collected from medical records.The Kaplan–Meier method was used to estimate overall survival(OS)and progression-free survival(PFS),and Cox’s proportional-hazards regression model was used to estimate hazard ratios and 95%confidence intervals.Results:Of all 13,328 patients,60.1%were men;the mean age was 61.3 years;53.5%had colon cancer.Among all patients,1,864(14.0%)were diagnosed with stage IV disease.The 3-and 5-year OS rates were 79.90%and 71.50%,respectively,whereas the 3-and 5-year PFS rates were 70.30%and 63.90%,respectively.The median OS and PFS times were 189 and 149 months,respectively.Among 13,328 patients,428(14.0%)patients with poor/undifferentiated cancer suffered recurrence.In patients with stageⅢand stageⅣdiseases,the median PFS times of the patients who received chemotherapy were significantly longer than those in patients who had not received chemotherapy(stageⅢ:147 vs 62 months,P<0.001;stageⅣ:14 vs 9.5 months,P<0.001).Conclusions:This retrospective cohort study illustrates the current status of the clinical characteristics of patients with CRC in southern China.Sex,age,family history,location of cancer occurrence,differentiation status,T status,N status,M status,clinical stage,operation,and surgical margin are independent factors associated with the OS of CRC patients. 关 键 词：colorectal cancer overall survival clinical characteristics PROGRESSION
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