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Liver HMGCS2 is critical in the maintenance of liver lipid homeostasis during fasting

查看全文 作  者:Yunfeng [1]Zhou;Tingting [2]Gu;Shuyuan [2]Hu;Zhaokang [1]Luo;Ling [1]Huang;Cong [1]Yu;Jie [3]Wang;Baohua [1]Liu;Xiaoyan [4]Zhang;Youfei [5]Guan 高影响力作者 机构地区:[1]Department of Physiology&Department of Biochemistry and Molecular Biology,Medical Research Center,Shenzhen University,Shenzhen,Guangdong 518060,China;[2]Division of Nephrology,Department of Internal Medicine,Nantong University Affiliated Hospital,Nantong,Jiangsu 226001,China;[3]Department of Internal Medicine,Shenzhen Guangming Maternity and Child Healthcare Hospital,Shenzhen,Guangdong 518000,China;[4]Health Science Center,East China Normal University,Shanghai 201109,China;[5]Advanced Institute for Medical Sciences,Dalian Medical University,Dalian,Liaoning 116044,China高影响力机构 出  处:《Genes & Diseases》索引2023年第10卷第3期,共4页高影响力期刊 基  金:supported by the National Natural Science Foundation of China(No.81970606,81970595,and 81970636);the Guangdong Medical Research Foundation(No.A2020260),China;the Shenzhen Basic Research Project(No.JCYJ20210324095005015),China;the SZU Top Ranking Project of China(No.86000000210). 摘  要:Fasting induces mammalian metabolic switch from glucose to fatty acid-derived ketones,resulting in a marked change in blood glucose,triglyceride,free fatty acid andβ-hydroxybutyrate levels and a phenotype of transient hepatic steatosis.However,the underlying mechanism remains incompletely understood. 关 键 词:INCOMPLETE CRITICAL TRANSIENT
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