Fungal mycobiome-mediated immune response:a non-negligible promoter in pancreatic oncogenesis and chemoresistance

查看全文 作　　者：Yaling [1]Jiang;Valentina [2,3]Donati;Godefridus [2,4]J.Peters;Elisa [2,5]Giovannetti;Dong Mei [1]Deng 机构地区：[1]Department of Preventive Dentistry,Academic Center for Dentistry Amsterdam(ACTA),University of Amsterdam and Vrije Universiteit Amsterdam,Amsterdam 1081 LA,Netherlands;[2]Department of Medical Oncology,Amsterdam University Medical Centers,location VUMC,Vrije Universiteit Amsterdam,Amsterdam 1081 HV,Netherlands;[3]Unit of Pathological Anatomy 2,Azienda Ospedaliero-Universitaria Pisana,Pisa 56100,Italy;[4]Department of Biochemistry,Medical University of Gdansk,Gdansk 80-210,Poland;[5]Fondazione Pisana per la Scienza ONLUS,San Giuliano Terme,Pisa 56017,Italy 出　　处：《Cancer Drug Resistance》索引2023年第6卷第2期,共7页 基　　金：This work was supported by grants from the Cancer Center Amsterdam(CCA)Foundation,As-sociazione Italiana per la Ricerca sul Cancro(AIRC)and Fondazione Pisana per la Scienza(FPS)to Giovannetti E,and the Dutch Research Council(NWO)(OCENW.XS22.4.135)to Jiang Y. 摘　　要：Pancreatic ductal adenocarcinoma(PDAC)is one of the most lethal cancers in humans due to late diagnosis and poor response to treatments.The tumor microenvironment(TME)of PDAC is characterized by a distinctive,suppressive immune profile,which inhibits the protective functions of anti-tumor immunity and thereby contributes to PDAC progression.Recently,the study of Alam et al.discovered for the first time that the intratumoral fungal mycobiome could contribute to the recruitment and activation of type 2 immune cells in the TME of PDAC via enhancing the secretion of a chemoattractant,interleukin(IL-)33.In this article,we reviewed the important findings of this study.Together with our findings,we synthetically discussed the role of the fungal mycobiome in orchestrating the immune response and thereby modulating tumor progression. 关 键 词：Mycobiome pancreatic cancer CHEMORESISTANCE interleukin 33 type 2 immune cells