Papillary fibroblast-recruiting injectable self-healing multifunctional hydrogels for wound regeneration

查看全文 作　　者：Yueyue [1]Li;Weifeng [2]Zhong;Junjie [1]Wu;Yuan [1]Jia;Zhonghua [1]Chen;Kaiwen [1]Zhang;Danyang [1]Guo;Yifei [1]Fu;Mengnan [1]Chen;Weiwei [1]Chen;Fan [1]Tian;Xia [1]Li;Hongji [2]Zhang;Xiaojin [1]Zhou;Feng-Lai [1]Yuan

机构地区：[1]Institute of Integrated Chinese and Western Medicine,Affiliated Hospital of Jiangnan University,Wuxi 214000,China;[2]The Key Laboratory of Synthetic and Biological Colloids,Ministry of Education,School of Chemical and Material Engineering,Jiangnan University,Wuxi 214000,China

出　　处：《Nano Research》索引2023年第16卷第7期,共12页

基　　金：Funding for this study was provided by the Natural Science Foundation of Jiangsu Province(No.BK20191141);Top Talent Support Program for Young and Middle-aged People of Wuxi Health Committee(Nos.BJ2020044,BJ2020057,and HB2020043);Fundamental Research Funds of Health and Family Planning Commission of Wuxi(No.M202024);the Special Program for Translational Medicine Research of Wuxi Translational Medicine Center(Nos.2020DHYB07 and 2020DHYB03);Key Special Project of Precision Medicine of Wuxi Health Commission(No.J202101). 摘　　要：The recruitment of key cells to regeneration sites is a promising strategy to promote functional wound healing.Dermal fibroblasts exhibit a heterogeneous population of cells during homeostasis and in response to injury.Papillary fibroblasts play central regulatory roles in the regeneration of skin appendages during wound healing.Inspired by the phenomenon where bait for grass carp can attract grouped grass carps to a fishing spot soon,“Grass Carp Fishing”multifunctional hydrogels,that is,codelivery of an antibody of leucine-rich repeats and immunoglobulin-like domains 1(Lrig1)on the surface of papillary fibroblasts and insulinlike growth factor 1(IGF1)with recruitment function,can recruit papillary fibroblasts.In the experiments,carboxymethyl chitosan showed positive effects in promoting cell proliferation and neovascularization,while dopamine-grafted gelatin was effective in stabilizing the structure and prolonging the degradation time.The sustained release of Lrig1 antibodies and IGF1 from injectable self-healing multifunctional hydrogels persistently accelerated the migration and proliferation of Lrig1+fibroblasts.The in vivo results from a full-thickness cutaneous wound model showed that injectable self-healing multifunctional hydrogel accelerated wound healing and skin regeneration through the recruitment of Lrig1+papillary fibroblasts in wound tissue.Our findings reveal an injectable self-healing multifunctional hydrogel for regeneration,a promising approach to promoting skin wound healing. 关键词：wound healing REGENERATION papillary fibroblasts recruitment

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Papillary fibroblast-recruiting injectable self-healing multifunctional hydrogels for wound regeneration

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