Research Article Ferric iron coordinated cisplatin prodrug reprograms the immunecold tumor microenvironment through tumor hypoxia relief for enhanced cancer photodynamic-immunotherapy

查看全文 作　　者：Yinchu [1,2]Ma;Yingli [1]Luo;Xinfeng [3]Tang;Wei [3]Jiang;Hongjun [4]Li;Jilong [5]Wang 机构地区：[1]Wuxi School of Medicine,Jiangnan University,Wuxi 214122,China;[2]Zhuhai Interventional Medical Center,Zhuhai Precision Medical Center,Zhuhai People's Hospital,Zhuhai Hospital Affiliated with Jinan University,Zhuhai 519000,China;[3]School of Life Sciences,University of Science and Technology of China,Hefei 230027,China;[4]Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China;[5]Joint Centre of Translational Medicine,Wenzhou Institute,University of Chinese Academy of Sciences,Wenzhou 325000,China 出　　处：《Nano Research》索引2023年第16卷第7期,共10页 基　　金：This work is supported by the National Natural Science Foundation of China(Nos.52103164,and 52173142);Guangdong Basic and Applied Basic Research Foundation(Nos.2021A1515220033 and 2020A1515111059);the Fundamental Research Funds for the Central Universities(No.JUSRP123079). 摘　　要：The microenvironment of hypoxia and immune-cold limits the therapeutic outcomes of immune checkpoint blockade(ICB)therapy in solid tumors.It is important and imperative to search new strategies to relieve tumor hypoxia and reverse immunosuppression of cold tumors.In this study,the oxygen(O_(2))self-replenishing nano-enabled coordination platform can be used to induce potent antitumor immune response in cold tumors.The nanoplatform can produce O_(2)by catalyzing hydrogen peroxide(H_(2)O_(2))in tumor site effectively,showing excellent photodynamic therapy(PDT)performance.Meanwhile,it can further trigger immunogenic cell death(ICD),enhance T cell infiltration,reverse immunosuppression,and reprogram the immune-cold tumor microenvironment.In vitro and in vivo results demonstrate that the nanoplatform has potential for eradicating tumors and long-term immunological memory effect.The nanoplatform opens up a strategy for reprograming the immunosuppressive microenvironment in cold tumors. 关 键 词：immunogenic cell death immune response reprograming cold tumor microenvironment long-term immunological memory effect