维普中文期刊产品整合服务

3D printed porous titanium filled with mineralized UV-responsive chitosan hydrogel promotes cell proliferation and osteogenesis in vitro

查看全文 作　　者：Jiazhao [1]Yang;Fan [2]Liu;Changshun [3]Zhou;Hejie [4]Li;Gaolin [4]Yang;Shiyuan [1]Fang;In-Seop [5]Lee;Yi [2]Liu;Hao [6]Bai;Cen [3,7]Chen 高影响力作者 机构地区：[1]The First Affiliated Hospital of USTC,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei 230001,China;[2]Department of Orthodontics,School of Stomatology,China Medical University,Shenyang 110002,China;[3]College of Life Sciences and Medicine,Zhejiang Sci-Tech University,Hangzhou 310018,China;[4]Institute of Laser Advanced Manufacturing,Zhejiang University of Technology,Hangzhou 310023,China;[5]Institute of Human Materials,Suwon 16514,Republic of Korea;[6]State Key Laboratory of Chemical Engineering,College of Chemical and Biological Engineering,Zhejiang University,Hangzhou 310027,China;[7]Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine,Hangzhou 310018,China高影响力机构 出　　处：《Journal of Materials Science & Technology》索引2023年第11期,共11页高影响力期刊 基　　金：financially supported partly by the Zhejiang Provincial Natural Science Foundation of China(No.LY20E010006);partly by the Fundamental Research Funds for the Central Universities(No.WK9110000152);partly by the Key Research and Development Plan of Anhui Province(No.20194a0720097);partly by the National Natural Science Foundation of China(Nos.51502265 and 81701033). 摘　　要：The modification of 3D printed porous titanium(Ti),especially for the internal pore structure,is critical and has received more attention to promoting its osteogenesis for clinical use.Ultra-violet(UV)responsive chitosan(CSMA),as an injectable filling material,was firstly incorporated into porous Ti,and then CSMA was in-situ mineralized by carbon oxide(CO_(2))diffusion(CSMA/CaCO_(3)).Their physical-chemical and biological properties were investigated in vitro.CaCO_(3) crystals within CSMA hydrogels were successfully deposited into pores of porous Ti,which exhibited favorable biocompatibility.Ti implants filled with CSMA/CaCO_(3) promoted adhesion and proliferation of bone mesenchymal stem cells(BMSCs).Moreover,Ti implant filled CSMA/CaCO_(3) hydrogels could increase alkaline phosphatase(ALP)activities,up-regulate osteopontin(OPN)and osteocalcin(OCN)expression levels,and enhance extracellular mineralization.3D printed porous Ti filled with mineralized UV-responsive chitosan hydrogel could promote proliferation and osteogenesis of BMSCs,and have great potential for the modification of porous Ti implants in bone tissue engineering. 关 键 词：Porous titanium Chitosan Ultraviolet(UV)-responsive MINERALIZATION OSTEOGENESIS
相关文献

参考文献(49)

引证文献(1)

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费