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A shape-persistent plasticine-like conductive hydrogel with self-healing properties for peripheral nerve regeneration

查看全文 作　　者：Xinchang [1]Kang;Xiaojun [1]Li;Can [5]Liu;Min [6]Cai;Pengfei [7]Guan;Yian [1]Luo;Youjun [1]Guan;Yu [1]Tian;Kunyu [1]Ren;Chengyun [4]Ning;Lei [3]Fan;Guoxin [1]Tan;Lei [2]Zhou 高影响力作者 机构地区：[1]School of Chemical Engineering and Light Industry,Guangdong University of Technology,Guangzhou 510006,China;[2]Department of Spine Surgery,Guangzhou Key Laboratory of Spine Disease Prevention and Treatment,the Third Affiliated Hospital,Guangzhou Medical University,Guangzhou 510150,China;[3]Department of Orthopedic Surgery,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China;[4]School of Materials Science and Engineering,South China University of Technology,Guangzhou 510641,China;[5]Department of Orthopedic Surgery,the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China;[6]Hospital of Stomatology,Guanghua School of Stomatology,Guangdong Provincial Key Laboratory of Stomatology,Sun Yat-sen University,Guangzhou 510055,China;[7]Department of Pediatric Orthopedic,Center for Orthopedic Surgery,the Third Affiliated Hospital of Southern Medical University,Guangzhou 510515,China高影响力机构 出　　处：《Journal of Materials Science & Technology》索引2023年第11期,共10页高影响力期刊 基　　金：financially supported by the National Natural Science Foundation of China(Nos.51932002 and 51903087);the Science and Technology Innovation Team Project of Foshan(No.2018IT100101);the Joint Fund of Ministry of Education for Equipment Preresearch(No.6141A02022632). 摘　　要：In recent years,electrically conductive hydrogel-based nerve guidance conduits(NGCs)have yielded promising results for treating peripheral nerve injuries(PNIs).However,developed ones are generally pre-manufactured and exhibit a limited ability to achieve good contact with nerve tissue with irregu-lar surfaces.Herein,we developed a plasticine-like electrically conductive hydrogel consisting of gelatin,conducting polypyrrole,and tannic acid(named GPT)and assessed its ability to promote peripheral nerve regeneration.The shape-persistent GPT hydrogel exhibited good self-healing properties and could easily be molded to form a conduit that could match any injured nerve tissue.Their electrical properties could be tuned by changing the PPy concentration.In vitro,the improved conductivity of the hydrogel pro-moted dorsal root ganglion(DRG)axonal extension.More importantly,we found that the GPT hydrogel enhanced axonal regeneration and remyelination in vivo,preventing denervation atrophy and enhancing functional recovery in a mice model of sciatic nerve injury.These results suggest that our plasticine-like NGC has huge prospects for clinical application in the repair of PNI. 关 键 词：Plasticine-like Conductive hydrogel SELF-HEALING Moldability Peripheral nerve conduit
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