The mechanisms linking adiposopathy to type 2 diabetes

查看全文 作　　者：Jichun [1]Yang;Jihong [1]Kang;Youfei [1]Guan

机构地区：[1]Department of Physiology and Pathophysiology,Peking University Diabetes Center,Peking University Health Science Center,Beijing 100191,China

出　　处：《Frontiers of Medicine》索引2013年第7卷第4期,共12页

基　　金：supported by grants from the Ministry of Science and Technology(Grant Nos.2012CB517504,2013CB945202,2010CB517504);the Natural Science Foundation of China(Grant Nos.81170791,81030003,81100398,81270943);supported by a grant from Beijing Natural Science Foundation(Grant No.7122107). 摘　　要：Obesity is defined as excessive accumulation of body fat in proportion to body size.When obesity occurs,the functions of adipose tissue may be deregulated,which is termed as adiposopathy.Adiposopathy is an independent risk factor for many diseases,including diabetes and cardiovascular diseases.In overweight or obese subjects with adiposopathy,hyperlipidemia exerts lipotoxicity in pancreatic islet and liver and induces pancreaticβcell dysfunction and liver insulin resistance,which are the decisive factors causing type 2 diabetes.Moreover,adipokines have been shown to play important roles in the regulation of glucose homeostasis.When adiposopathy occurs,abnormal changes in the serum adipokine profile correlate with the development and progression of pancreaticβcell dysfunction and insulin resistance in peripheral tissue.The current paper briefly discusses the latest findings regarding the effects of adiposopathy-related lipotoxicity and cytokine toxicity on the development of type 2 diabetes. 关键词：OBESITY adiposopathy LIPOTOXICITY ADIPOKINES DIABETES

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The mechanisms linking adiposopathy to type 2 diabetes

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