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Analysis and Identification of the Chemical Constituents of Ding-Zhi-Xiao-Wan Prescription by HPLC-IT-MSn and HPLC-Q-TOF-MS

查看全文 作　　者：Shiyao [1,2]Tang;Shu [1]Liu;Zhiqiang [1]Liu;Fengrui [1]Song;Shuying [1]Liu 高影响力作者 机构地区：[1]Changchun Center of Mass Spectrometry&Chemical Biology Laboratory,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun,Jilin 130022,China;[2]University of Chinese Academy of Sciences,Beijing 100039,China高影响力机构 出　　处：《Chinese Journal of Chemistry》索引2015年第33卷第4期,共12页高影响力期刊 基　　金：the National Natural Sci-ence Foundation of China(Grant No.21175128,81303280,81373952)for the financial support for this work. 摘　　要：Ding-Zhi-Xiao-Wan(DZXW)is a famous traditional Chinese medicine(TCM)formula,which is composed of four herbs,Ginseng Radix,Poria,Polygala Radix and Acori Tatarinowii Rhizoma.It has been popularly used for the treatment of emotional disease,like Alzheimer’s disease,Parkinson’s disease,depression,anxiety,forgetfulness and neurasthenia.In this research,a high-performance liquid chromatography coupled with ion-trap tandem mass spectrometry(HPLC-IT-MS^(n))method along with a high-performance liquid chromatography coupled with quadru-pole time-of-flight mass spectrometry(HPLC-Q-TOF-MS)method in negative ion mode was established to inves-tigate the major constitutions in DZXW.The extracts were prepared by ultra-sonication in ethyl acetate,n-butanol,95%ethanol and deionized water sequentially as well as in deionized water directly.A Kromasil C18 column was used to separate the extracts of DZXW.Acetonitrile and 0.1%aqueous formic acid(V/V)were used as the mobile phase.A total of 64 components were characterized,including 16 triterpenoids,14 Polygala saponins,10 oligosac-charide esters,6 sucrose esters,2 xanthone C-glycosides and 16 ginsenosides. 关 键 词：Ding-Zhi-Xiao-Wan chemical constituents HPLC-IT-MSn HPLC-Q-TOF-MS
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