Senolysis through thrombomodulation

查看全文 作　　者：Corey [1]M.Webster;Jan M.van [2]Deursen 机构地区：[1]Buck Institute for Research on Aging,Novato,CA,USA.;[2]Cavalry Biosciences,Novato and San Francisco,CA,USA 出　　处：《Cell Research》索引2023年第33卷第8期,共2页 摘　　要：In a recent study published in Cell Research,Pan et al.show that thrombomodulin(THBD),a cell surface glycoprotein activator of the thrombin-mediated MAPK pathway,is a key determinant of senescent cell fate.Using the FDA-approved THBD pathway inhibitor,vorapaxar,or depletion of THBD signaling,they show that inhibition or depletion of the THBD pathway acts as a novel senolytic mechanism and restores homeostasis in liver fibrosis models. 关 键 词：THROMBO HOMEOSTASIS