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Selenium deficiency-induced multiple tissue damage with dysregulation of immune and redox homeostasis in broiler chicks under heat stress

查看全文 作　　者：Ling [1]Zhao;Meng [1]Liu;Hua [1]Sun;Jia-Cheng [1]Yang;Yu-Xuan [1]Huang;Jia-Qiang [2]Huang;Xingen [3]Lei;Lv-Hui [1]Sun 高影响力作者 机构地区：[1]State Key Laboratory of Agricultural Microbiology,Hubei Hongshan Laboratory,Frontiers Science Center for Animal Breeding and Sustainable Production,College of Animal Sciences and Technology,Huazhong Agricultural University,Wuhan 430070,China;[2]Beijing Advanced Innovation Center for Food Nutrition and Human Health,Department of Nutrition and Health,China Agricultural University,Beijing 100083,China;[3]Department of Animal Science,Cornell University,Ithaca 14853,USA高影响力机构 出　　处：《Science China(Life Sciences)》索引2023年第66卷第9期,共14页高影响力期刊 基　　金：supported by the National Natural Science Foundation of China (32102588);the Top-notch Young Talent Supporting Program to LHS;Beijing Deyuanshun Biological Technology Co.,Ltd。 摘　　要：Broiler chicks are fast-growing and susceptible to dietary selenium(Se) deficiency. This study sought to reveal the underlying mechanisms of how Se deficiency induces key organ dysfunctions in broilers. Day-old male chicks(n=6 cages/diet, 6 chicks/cage) were fed with a Se-deficient diet(Se-Def, 0.047 mg Se/kg) or the Se-Def+0.3 mg Se/kg(Control, 0.345 mg Se/kg) for 6weeks. The serum, liver, pancreas, spleen, heart, and pectoral muscle of the broilers were collected at week 6 to assay for Se concentration, histopathology, serum metabolome, and tissue transcriptome. Compared with the Control group, Se deficiency induced growth retardation and histopathological lesions and reduced Se concentration in the five organs. Integrated transcriptomics and metabolomics analysis revealed that dysregulation of immune and redox homeostasis related biological processes and pathways contributed to Se deficiency-induced multiple tissue damage in the broilers. Meanwhile, four metabolites in the serum, daidzein, epinephrine, L-aspartic acid and 5-hydroxyindoleacetic acid, interacted with differentially expressed genes with antioxidative effects and immunity among all the five organs, which contributed to the metabolic diseases induced by Se deficiency. Overall, this study systematically elucidated the underlying molecular mechanisms in the pathogenesis of Se deficiency-related diseases, which provides a better understanding of the significance of Se-mediated heath in animals. 关 键 词：SELENIUM multiple tissue damage METABOLOME TRANSCRIPTOME BROILERS
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