HIV-1 Subtype Diversity and Factors Affecting Drug Resistance among Patients with Virologic Failure in Antiretroviral Therapy in Hainan Province,China,2014–2020

查看全文 作　　者：YU De [1,2]E;XU Yu [3]Jun;LI [1]Mu;YANG [4]Yuan;LIANG Hua [1]Yue;ZHONG Shan [1]Mei;QIN [1]Cai;LAN Ya [5]Nan;LI Da [1]Wei;YU Ji [6]Peng;PANG [1]Yuan;QIN Xue [1]Qiu;LIANG [1,4]Hao;ZHU Kao [3]Kao;YE [1,4]Li;LIANG Bing [1,4]Yu

机构地区：[1]Guangxi Key Laboratory of AIDS Prevention and Treatment,School of Public Health,Guangxi Medical University,Nanning 530021,Guangxi,China;[2]International School of Public Health and One Health,Hainan Medical University,Haikou 571199,Hainan,China;[3]Prevention and Treatment Department,the Fifth People's Hospital of Hainan Province&Affiliated Dermatology Hospital of Hainan Medical University,Haikou 570102,Hainan,China;[4]Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry,Life Sciences Institute,Guangxi Medical University,Nanning 530021,Guangxi,China;[5]Oncology Medical College,Guangxi Medical University,Nanning 530021,Guangxi,China;[6]The First Clinical Medical College,Guangxi Medical University,Nanning 530021,Guangxi,China,Guangxi Key Laboratory of AIDS Prevention and Treatment,School of Public Health,Guangxi Medical University,Nanning 530021,Guangxi,China

出　　处：《Biomedical and Environmental Sciences》索引2023年第36卷第9期,共14页

基　　金：supported by grants from the 2021 Graduate Education Innovation Program Project of Guangxi Zhuang Autonomous Region [YCBZ2021041];the National innovative training program for college students [202100001580];grants from the National Natural Science Foundation of China [NSFC,31860040]。 摘　　要：Objective This study aimed to determine the HIV-1 subtype distribution and HIV drug resistance(HIVDR)in patients with ART failure from 2014 to 2020 in Hainan,China.Methods A 7-year cross-sectional study was conducted among HIV/AIDS patients with ART failure in Hainan.We used online subtyping tools and the maximum likelihood phylogenetic tree to confirm the HIV subtypes with pol sequences.Drug resistance mutations(DRMs)were analyzed using the Stanford University HIV Drug Resistance Database.Results A total of 307 HIV-infected patients with ART failure were included,and 241 available pol sequences were obtained.Among 241 patients,CRF01_AE accounted for 68.88%,followed by CRF07_BC(17.00%)and eight other subtypes(14.12%).The overall prevalence of HIVDR was 61.41%,and the HIVDR against non-nucleoside reverse transcriptase inhibitors(NNRTIs),nucleotide reverse transcriptase inhibitors(NRTIs),and protease inhibitors(PIs)were 59.75%,45.64%,and 2.49%,respectively.Unemployed patients,hypoimmunity or opportunistic infections in individuals,and samples from 2017 to 2020 increased the odd ratios of HIVDR.Also,HIVDR was less likely to affect female patients.The common DRMs to NNRTIs were K103N(21.99%)and Y181C(20.33%),and M184V(28.21%)and K65R(19.09%)were the main DRMs against NRTIs.Conclusion The present study highlights the HIV-1 subtype diversity in Hainan and the importance of HIVDR surveillance over a long period. 关键词：HIV-1 subtypes Antiretroviral therapy Virological failure Drug resistance

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HIV-1 Subtype Diversity and Factors Affecting Drug Resistance among Patients with Virologic Failure in Antiretroviral Therapy in Hainan Province,China,2014–2020

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