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Simultaneous detection of enterovirus-D68 and vaccine-related poliovirus 3 in the stool samples of a 5-month hospitalized child with acute respiratory disease:A case report

查看全文 作　　者：Wenzhe [1,2]Su;Qing [1,2]Zeng;Jinmei [1,2]Geng;Jingwen [1,2]Liu;Huaping [1,2]Xie;Kuibiao [1,2]Li;Pengzhe [1,2]Qin;Chaojun [3]Xie;Biao [1,2]Di 高影响力作者 机构地区：[1]Guangzhou Center for Disease Control and Prevention,Guangzhou 510000,China;[2]Institute of Public Health,Guangzhou Medical University&Guangzhou Center for Disease Control and Prevention,Guangzhou 510000,China;[3]Huadu Center for Disease Control and Prevention,Guangzhou 510803,China高影响力机构 出　　处：《Biosafety and Health》索引2023年第5卷第4期,共4页高影响力期刊 基　　金：supported by the Key Project of Medicine Discipline of Guangzhou(2021-2023-11);the Science and Technology Project of Guangzhou(2023A03J0447). 摘　　要：Human enterovirus(EV)infections can lead to various manifestations,with variable correlations between genotypes and symptoms.Human enterovirus D68(EV-D68)was considered to be associated with acute respiratory disease and acute flaccid myelitis.In this short report,both EV-D68 and poliovirus 3 were detected in the stool of a hospitalized 5-month child who presented with acute respiratory symptoms and who was recently vaccinated with oral polio vaccine(OPV),using a metatranscriptomic high-throughput sequencing method.The nearly full-length genome sequences with complete open reading frames of EV-D68 and poliovirus 3 were assembled.One previously-reported neurovirulence-related amino acid substitution(T860N)in the EV-D68 VP1 region was observed,but the patient showed no neurological symptoms.More attention should be paid to EV-D68,and continuous multiple syndrome-based surveillance on non-polio enterovirus is called for. 关 键 词：ENTEROVIRUS EV-D68 Poliovirus 3 Acute respiratory disease Whole genome sequencing CO-INFECTION
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