Isatis indigotica:from(ethno)botany,biochemistry to synthetic biology

查看全文 作　　者：Jingxian [1]Feng;Doudou [1]Huang;Yingbo [1,2]Yang;Junfeng [1]Chen;Shi [1]Qiu;Zongyou [1]Lv;Xueqi [1]Ma;Yuanyu [1]Li;Rongrong [1]Li;Ying [1]Xiao;Wansheng [1,3]Chen

机构地区：[1]Research and Development Center of Chinese Medicine Resources and Biotechnology,The Ministry of Education(MOE)Key Laboratory for Standardization of Chinese Medicines,Institute of Chinese Materia Medica,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;[2]Jiangsu Kanion Pharmaceutical Co.,Ltd,Jiangsu 222001,Lianyungang,China;[3]Medical Guarantee Center,Changzheng Hospital,Naval Medical University,Shanghai 200003,China

出　　处：《Molecular Horticulture》索引2021年第1卷第1期,共14页

基　　金：This work was supported by the National Natural Science Foundation of China(32170402 and 81874335 to Y.X.,31872665 to W.C.,82003897 to J.F.);the Shanghai local Science and Technology Development Fund Program guided by the Central Government(YDZX20203100002948 to W.C.). 摘　　要：Isatis indigotica Fort.(Chinese woad)is a species with an ancient and well-documented history as an indigo dye and medicinal plant.It is often confused with Isatis tinctoria L.(European woad),a medicinal plant in Europe.Here,the differences between I.indigotica and I.tinctoria are systematically described.The usage development history,clinical applications and pharmacological activities,and chemical components of I.indigotica are also summarized.Lignans,indole alkaloids,and their corresponding derivatives have been identified as the major active ingredients of I.indigotica and are associated with anti-viral,anti-inflammatory,anti-cancer,and other health-promoting activities.Notable progress has been made in understanding the biosynthetic pathway and regulation mechanism of lignans and indole alkaloids in I.indigotica,the results from which should facilitate the process of targeted metabolic engineering or synthetic biology.Moreover,multiple biotechnology methods such as polyploid breeding and genetic engineering have been used with I.indigotica to result in,for example,greater yields,higher levels of bioactive component accumulation,and enhanced stress tolerance to salt,drought,and insects.Some issues require additional analyses,and suggestions for future research on I.indigotica are also discussed. 关键词：Isatis indigotica Lignans Indole alkaloids Metabolic engineering Synthetic biology

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Isatis indigotica:from(ethno)botany,biochemistry to synthetic biology

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