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The Janus-faced role of Piezo1 in cardiovascular health under mechanical stimulation

查看全文 作　　者：Junyang [1]Huang;Kun [1]Zhang;Ruolin [1]Du;Wanling [1]Liu;Haijun [2]Zhang;Tian [1]Tian;Yazhou [3]Wang;Guixue [1]Wang;Tieying [1]Yin 高影响力作者 机构地区：[1]Key Laboratory for Biorheological Science and Technology of Ministry of Education,State and Local Joint Engineering Laboratory for Vascular Implants,Bioengineering College of Chongqing University,Chongqing 400030,China;[2]Department of Vascular&Intervention,Tenth Peoples'Hospital of Tongji University,Shanghai 200072,China;[3]School of Medicine,Chongqing University,Chongqing 400030,China高影响力机构 出　　处：《Genes & Diseases》索引2023年第10卷第5期,共13页高影响力期刊 基　　金：supported by National Natural Science Foundation of China(No.31971242,and 12032007);the Natural Science Foundation of Chongqing(No.cstc2019jcyjmsxmX0307,cstc2019jcyj-19zdxmx0009,and cstc2019jcyjzdxmX0028). 摘　　要：In recent years,cardiovascular health problems are becoming more and more serious.At the same time,mechanical stimulation closely relates to cardiovascular health.In this context,Piezo1,which is very sensitive to mechanical stimulation,has attracted our attention.Here,we review the critical significance of Piezo1 in mechanical stimulation of endothelial cells,NO production,lipid metabolism,DNA damage protection,the development of new blood vessels and maturation,narrowing of blood vessels,blood pressure regulation,vascular permeability,insulin sensitivity,and maintenance of red blood cell function.Besides,Piezo1 may participate in the occurrence and development of atherosclerosis,diabetes,hypertension,and other cardiovascular diseases.It is worth noting that Piezo1 has dual effects on maintaining cardiovascular health.On the one hand,the function of Piezo1 is necessary to maintain cardiovascular health;on the other hand,under some extreme mechanical stimulation,the overexpression of Piezo1 may bring adverse factors such as inflammation.Therefore,this review discusses the Janus-faced role of Piezo1 in maintaining cardiovascular health and puts forward new ideas to provide references for gene therapy or nanoagents targeting Piezo1. 关 键 词：ATHEROSCLEROSIS Cardiovascular disease Endothelial cells(ECs) Mechanical stimulation Piezo1
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