Interplays of liver fibrosis-associated microRNAs:Molecular mechanisms and implications in diagnosis and therapy

查看全文 作　　者：Hong [1]Li;Tingli [1]Liu;Yongchun [2]Yang;William [3]C.Cho;Robin [4,5]J.Flynn;Majid Fasihi [6]Harandi;Houhui [2]Song;Xuenong [1]Luo;Yadong [2]Zheng

机构地区：[1]State Key Laboratory of Veterinary Etiological Biology,Key Laboratory of Veterinary Parasitology of Gansu Province,Lanzhou Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Lanzhou,Gansu 730046,China;[2]Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province,Zhejiang Provincial Engineering Laboratory for Animal Health Inspection&Internet Technology,Zhejiang International Science and Technology Cooperation Base for Veterinary Medicine and Health Management,China-Australia Joint Laboratory for Animal Health Big Data Analytics,College of Animal Science and Technology&College of Veterinary Medicine of Zhejiang A&F University,Hangzhou,Zhejiang 311300,China;[3]Department of Clinical Oncology,Queen Elizabeth Hospital,Hong Kong SAR 999077,China;[4]Department of Infection Biology,Institute of Infection and Global Health,University of Liverpool,Liverpool L35RF,UK;[5]Graduate Studies Office,Department of Research,Innovation and Graduate Studies,Waterford Institute of Technology,X91 K0EK,Ireland;[6]Research Center for Hydatid Disease in Iran,Kerman University of Medical Sciences,Kerman 7616914115,Iran

出　　处：《Genes & Diseases》索引2023年第10卷第4期,共13页

基　　金：supported by grants from the National Natural Science Foundation of China(No.32072889,U1703104);Key R&D Program of Zhejiang Province(China)(No.2019C02052);Scientific Research and Development Talent Fund of Zhejiang Agriculture and Forestry University,China(No.2021LFR038). 摘　　要：microRNAs(miRNAs)are a class of non-coding functional small RNA composed of 21e23 nucleotides,having multiple associations with liver fibrosis.Fibrosis-associated miRNAs are roughly classified into pro-fibrosis or anti-fibrosis types.The former is capable of activating hepatic stellate cells(HSCs)by modulating pro-fibrotic signaling pathways,mainly including TGF-b/SMAD,WNT/b-catenin,and Hedgehog;the latter is responsible for maintenance of the quiescent phenotype of normal HSCs,phenotypic reversion of activated HSCs(aHSCs),inhibition of HSCs proliferation and suppression of the extracellular matrix-associated gene expression.Moreover,several miRNAs are involved in regulation of liver fibrosis via alternative mechanisms,such as interacting between hepatocytes and other liver cells via exosomes and increasing autophagy of aHSCs.Thus,understanding the role of these miRNAs may provide new avenues for the development of novel interventions against hepatic fibrosis. 关键词：Diagnosis Hepatic stellate cell Liver fibrosis miRNA THERAPY

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Interplays of liver fibrosis-associated microRNAs:Molecular mechanisms and implications in diagnosis and therapy

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