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Porcine intestinal antimicrobial peptide as an in-feed antibiotic alternative improves intestinal digestion and immunity by shaping the gut microbiota in weaned piglets

查看全文 作　　者：Fengjie [1,2]Ji;Huansheng [1]Yang;Qiye [1]Wang;Jianzhong [1]Li;Hanlin [3]Zhou;Shengmin [3]Liu 高影响力作者 机构地区：[1]Hunan International Joint Laboratory of Animal Intestinal Ecology and Health,Laboratory of Animal Nutrition and Human Health,College of Life Sciences,Hunan Normal University,Changsha,410081,China;[2]Tropical Crops Genetic Resources Institute,Chinese Academy of Tropical Agricultural Sciences,Haikou,571101,China;[3]Hainan Agri-Farming Animal Husbandry Group Co.,Ltd.,Haikou,570226,China高影响力机构 出　　处：《Animal Nutrition》索引2023年第3期,共13页高影响力期刊 基　　金：jointly supported by Changsha-ZhuzhouXiangtan National Independent Innovation Demonstration Zone projects(Grant No.2017XK2058);High-Level Talent Concentration Project(Grant No.2017XK2022);Hainan Modern Agricultural Production Research System(Grant No.HNARS2022-2-G3)。 摘　　要：Antibiotic resistance of pathogens,which is caused by the abuse of in-feed antibiotics,threatens the sustainable development of livestock production.The present study aimed to investigate the efficiency of porcine intestinal antimicrobial peptide(PIAP)as an alternative to in-feed antibiotics in terms of growth performance,intestinal morphology,digestive enzymes and immunity,and microbiota community of the post-weaning piglets.A total of 204 piglets(Duroc×Landrace×Yorkshire,weaned at 28 d age)with a similar body weight of 7.97±1.04 kg were randomly allocated to 4 groups(51 piglets per group):(1)control group:basal diet;(2)AB group:antibiotic,basal diet+chlortetracycline(1000 mg/kg from d 1 to24;500 mg/kg from d 25 to 37);(3)P1 group:basal diet+a relatively low dose of PIAP(400 mg/kg from d 1 to 24;300 mg/kg from d 25 to 37);(4)P2 group,basal diet+a relatively high dose of PIAP(600 mg/kg from d 1 to 24;500 mg/kg from d 25 to 37).The results showed that serum indicators of hepatocyte damage and relative organ weight were not affected by these treatments(P>0.05).Compared with the AB treatment,the P1 treatment remarkably decreased jejunal crypt depth and increased jejunal and ileal villus height:crypt depth ratio(P<0.05).The values of jejunal maltase,lactase,sucrase,intestinal alkaline phosphatase,and secretory immunoglobulin A(SIg A)in the P1 group were sharply increased compared with those in the control and P2 groups(P<0.05).Compared with the control group,the P1 group decreased serum concentrations of D-lactate,diamine oxidase,and endotoxin(P<0.05),and increased the abundance of Lactobacillus reuteri(P<0.05)in the colonic feces.Furthermore,there was a positive correlation between the abundance of L.reuteri and the concentrations of maltase,lactase,sucrase,and SIg A(P<0.05).Collectively,dietary supplementation with a relatively low dose of PIAP(400 mg/kg from d 1 to 24;300 mg/kg from d 25 to 37)demonstrates beneficial effects on intestinal morphology,digestive enzymes,immunity,and permeability by shaping the gut microbiota composition in weaned piglets.This study will provide a valuable reference for using PIAP as an in-feed antibiotic alternative in swine production. 关 键 词：Weaned piglet Antibiotic alternative Antimicrobial peptide Colonic microbiota Intestinal function
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