RNA modification in cardiovascular disease: implications for therapeutic interventions

查看全文 作　　者：Cong [1,2]Wang;Xuyang [1,2]Hou;Qing [1,2]Guan;Huiling [1,2]Zhou;Li [3]Zhou;Lijun [1,2]Liu;Jijia [1]Liu;Feng [1]Li;Wei [4]Li;Haidan [1,2]Liu

机构地区：[1]Department of Cardiovascular Surgery,The Second Xiangya Hospital of Central South University,Changsha,Hunan,China;[2]Clinical Center for Gene Diagnosis and Therapy,The Second Xiangya Hospital of Central South University,Changsha,Hunan,China;[3]Department of Pathology,National Clinical Research Center for Geriatric Disorders,The Xiangya Hospital of Central South University,Changsha,Hunan,China;[4]Department of Radiology,The Third Xiangya Hospital of Central South University,Changsha,Hunan,China

出　　处：《Signal Transduction and Targeted Therapy》索引2023年第8卷第11期,共22页

基　　金：the National Natural Science Foundation of China(Grant No.82073260,82003203,81972837,81572280);the Natural Science Foundation of Hunan Province(Grant No.2023JJ30766,2023JJ10091,2021JJ41058,2019J40420). 摘　　要：Cardiovascular disease(CVD)is the leading cause of death in the world,with a high incidence and a youth-oriented tendency.RNA modification is ubiquitous and indispensable in cell,maintaining cell homeostasis and function by dynamically regulating gene expression.Accumulating evidence has revealed the role of aberrant gene expression in CVD caused by dysregulated RNA modification.In this review,we focus on nine common RNA modifications:N^(6)-methyladenosine(m^(6)A),N^(1)-methyladenosine(m^(1)A),5-methylcytosine(m^(5)C),N^(7)-methylguanosine(m^(7)G),N^(4)-acetylcytosine(ac^(4)C),pseudouridine(Ψ),uridylation,adenosine-to-inosine(A-to-I)RNA editing,and modifications of U34 on tRNA wobble.We summarize the key regulators of RNA modification and their effects on gene expression,such as RNA splicing,maturation,transport,stability,and translation.Then,based on the classification of CVD,the mechanisms by which the disease occurs and progresses through RNA modifications are discussed.Potential therapeutic strategies,such as gene therapy,are reviewed based on these mechanisms.Herein,some of the CVD(such as stroke and peripheral vascular disease)are not included due to the limited availability of literature.Finally,the prospective applications and challenges of RNA modification in CVD are discussed for the purpose of facilitating clinical translation.Moreover,we look forward to more studies exploring the mechanisms and roles of RNA modification in CVD in the future,as there are substantial uncultivated areas to be explored. 关键词：THERAPEUTIC HOMEOSTASIS MODIFICATION

相关文献

参考文献（377）
引证文献（3）
耦合文献（956）

参考文献(377)

引证文献(3)

耦合文献(956)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

RNA modification in cardiovascular disease: implications for therapeutic interventions

参考文献(377)

引证文献(3)

耦合文献(956)

用户提示