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Long noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the miR-627-3p/SPRED1 axis

查看全文 作　　者：Pengfei [1]Zhao;Yating [2]Wang;Xiao [1]Yu;Yabing [1]Nan;Shi [1]Liu;Bin [2]Li;Zhumei [3]Cui;Zhihua [1]Liu 高影响力作者 机构地区：[1]State Key Laboratory of Molecular Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100021,China;[2]Department of Gynecological Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100021,China;[3]Department of Obstetrics and Gynecology,The Affiliated Hospital of Qingdao University,Qingdao,266000,China高影响力机构 出　　处：《Frontiers of Medicine》索引2023年第17卷第5期,共15页高影响力期刊 基　　金：supported by the National Key R&D Program of China (No.2021YFC2501000);the CAMS Innovation Fund for Medical Sciences (Nos.2021-I2M-1-018 and 2021-12M-1-067). 摘　　要：Long noncoding RNAs(lncRNAs)play a crucial regulatory role in the development and progression of multiple cancers.However,the potential mechanism by which lncRNAs affect the recurrence and metastasis of ovarian cancer remains unclear.In the current study,the lncRNA LOC646029 was markedly downregulated in metastatic ovarian tumors compared with primary tumors.Gain-and loss-of-function assays demonstrated that LOC646029 inhibits the proliferation,invasiveness,and metastasis of ovarian cancer cells in vivo and in vitro.Moreover,the downregulation of LOC646029 in metastatic ovarian tumors was strongly correlated with poor prognosis.Mechanistically,LOC646029 served as a miR-627-3p sponge to promote the expression of Sprouty-related EVH1 domain-containing protein 1,which is necessary for suppressing tumor metastasis and inhibiting KRAS signaling.Collectively,our results demonstrated that LOC646029 is involved in the progression and metastasis of ovarian cancer,which may be a potential prognostic biomarker. 关 键 词：0varian cancer lncRNA LOC646029 METASTASIS microRNA 627-3p SPRED1
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