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Differences in the effects and action modes of gut commensals against dextran sulfate sodium-induced intestinal inflammation

查看全文 作　　者：Dingwu [1,2]Qu;Zhennan [1,2]Gu;Saisai [1,2]Feng;Leilei [1,2]Yu;Fengwei [1,2]Tian;Hao [1,2,3,4]Zhang;Wei [1,2,3]Chen;Qixiao [1,2]Zhai 高影响力作者 机构地区：[1]State Key Laboratory of Food Science and Technology,Jiangnan University,Wuxi 214122,China;[2]School of Food Science and Technology,Jiangnan University,Wuxi 214122,China;[3]National Engineering Research Center for Functional Food,Jiangnan University,Wuxi 214122,China;[4]Wuxi Translational Medicine Research Center and Jiangsu Translational Medicine Research Institute Wuxi Branch,Wuxi 214122,China高影响力机构 出　　处：《Food Science and Human Wellness》索引2024年第13卷第3期,共11页高影响力期刊 基　　金：supported by the Natural Science Foundation of Jiangsu Province (BK20200084);The National Natural Science Foundation of China (U1903205 and 31972971);Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province。 摘　　要：Inflammatory bowel disease(IBD)is a complex relapsing inflammatory disease in the gut and is driven by complicated host-gut microbiome interactions.Gut commensals have shown different functions in IBD prevention and treatment.To gain a mechanistic understanding of how different commensals affect intestinal inflammation,we compared the protective effects of 6 probiotics(belonging to the genera Akkermansia,Bifidobacterium,Clostridium,and Enterococcus)on dextran sulfate sodium(DSS)-induced colitis in mice with or without gut microbiota.Anti-inflammatory properties(ratio of interleukin(IL)-10 and IL-12)of these strains were also evaluated in an in vitro mesenteric lymph nodes(MLN)co-culture system.Results showed that 4 probiotics(belonging to the species Bifidobacterium breve,Bifidobacterium bifidum,and Enterococcus faecalis)can alleviate colitis in normal mice.The probiotic strains differed in regulating the intestinal microbiota,cytokines(IL-10,IL-1βand interferon(IFN)-γ),and tight junction function(Zonulin-1 and Occludin).By constrast,Akkermansia muciniphila AH39 and Clostridium butyricum FHuNHHMY49T1 were not protective.Interestingly,B.breve JSNJJNM2 with high anti-inflammatory potential in the MLN model could relieve colitis symptoms in antibiotic cocktail(Abx)-treated mice.Meanwhile,E.faecalis FJSWX25M1induced low levels of cytokines in vitro and showed no beneficial effects.Therefore,we provided insight into the clinical application of probiotics in IBD treatment. 关 键 词：Gut commensals Dextran sulfate sodium(DSS)colitis Intestinal barrier IMMUNOREGULATION
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