Luteolin suppresses oral carcinoma 3(OC3) cell growth and migration via modulating polo-like kinase 1(PLK1) expression and cellular energy metabolism

查看全文 作　　者：Pengfei [1,2]GAO;Wentao [1]ZHANG;Yujie [3]LIN;Ruijie [3]LU;Zijian [3]LOU;Gang [4]LU;Ruolang [4]PAN;Yunfang [1,2]CHEN

机构地区：[1]Center for Plastic&Reconstructive Surgery,Department of Stomatology,Zhejiang Provincial People's Hospital(Affiliated People's Hospital),Hangzhou Medical College,Hangzhou 310014,China;[2]School of Stomatology,Bengbu Medical College,Bengbu 233030,China;[3]The Second Clinical Medical College,Wenzhou Medical University,Wenzhou 325035,China;[4]Key Laboratory of Cell-Based Drug and Applied Technology Development in Zhejiang Province,Hangzhou 31122,China

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》索引2023年第24卷第12期,共8页

基　　金：supported by the Zhejiang Provincial Traditional Chinese Medicine Science and Technology Project(Nos.2019ZB015 and 2019ZA014),China. 摘　　要：Oral squamous cell carcinoma(OSCC)is a prevalent malignant tumor affecting the head and neck region(Leemans et al.,2018).It is often diagnosed at a later stage,leading to a poor prognosis(Muzaffar et al.,2021;Li et al.,2023).Despite advances in OSCC treatment,the overall 5-year survival rate of OSCC patients remains alarmingly low,falling below 50%(Jehn et al.,2019;Johnson et al.,2020).According to statistics,only 50%of patients with oral cancer can be treated with surgery.Once discovered,it is more frequently at an advanced stage.In addition,owing to the aggressively invasive and metastatic characteristics of OSCC,most patients die within one year of diagnosis.Hence,the pursuit of novel therapeutic drugs and treatments to improve the response of oral cancer to medication,along with a deeper understanding of their effects. 关键词：PLK1 METABOLISM DRUGS

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Luteolin suppresses oral carcinoma 3(OC3) cell growth and migration via modulating polo-like kinase 1(PLK1) expression and cellular energy metabolism

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