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Clinical validation of serum immunosignatures in early diagnosis of Crohn's disease

查看全文 作　　者：Xianzong [1,2]Ma;Wenyu [3]Zhang;Xin [2]Wang;Lang [2,4]Yang;Juan [5]Jiao;Yan [2]Jia;Dezhi [1,2]Wang;Junfeng [4]Xu;Peng [2,4]Jin;Mingjie [2]Zhang;Shirong [2]Li;Yuanming [6]Pan;Jianqiu [1,2,4]Sheng 高影响力作者 机构地区：[1]Medical School of Chinese PLA,Chinese PLA General Hospital,Beijing,China;[2]Department of Gastroenterology,The Seventh Medical Center of Chinese PLA General Hospital,Beijing,China;[3]Capital Medical University,Beijing,China;[4]Senior Department of Gastroenterology,The First Medical Center of Chinese PLA General Hospital,Beijing,China;[5]Laboratory Medicine Center,The Seventh Medical Center of Chinese PLA General Hospital,Beijing,China;[6]Cancer Research Center,Beijing Chest Hospital,Capital Medical University,Beijing,China高影响力机构 出　　处：《iLABMED》索引2023年第1卷第3期,共9页高影响力期刊 摘　　要：Background:The search for biomarkers suitable for early diagnosis of Crohn's disease(CD)is challenging.This study investigated the efficacy of serological markers for the early diagnosis of CD.Methods:This was a retrospective nested cohort study.Indirect immuno-fluorescence and enzyme‐linked immunosorbent assay were used to detect ASCA IgG,ASCA IgA,AYMA IgG,AYCA IgG,FI2Y IgG,p‐ANCA IgG,GAB IgG and PAB IgG in patient serum samples.Results:The positive rates of ASCA IgG,ASCA IgA,AYMA IgG,AYCA IgG,FI2Y IgG,p‐ANCA IgG,GAB IgG and PAB IgG in patients with early CD,advanced CD and other intestinal diseases were 37.0%versus 56.8%versus 27.8%;3.7%versus 20.5%versus 19.4%;14.8%versus 2.3%versus 2.8%;25.9%versus 9.1%versus 8.3%;18.5%versus 15.9%versus 8.3%;0.0%versus 2.8%,18.5%;13.6%versus 18.2%versus 16.7%;and 7.4%versus 20.5%versus 0.0%,respectively.The positive rates of ASCA IgG,AYCA IgG and PAB IgG were significantly different among the three groups(p<0.05).In 85.2%of early CD patients,at least one antibody was detected 1 year before diagnosis.The sensitivity of the ASCA/AYMA/AYCA/FI2Y/GAB combination for early diagnosis was 85.2%.The sensitivity of the ASCA/AYMA/AYCA/FI2Y/GAB/PAB/PANCA combination for differentiating CD from other diseases was 87.3%.Conclusions:ASCA IgG and AYCA IgG have potential value in identifying the course of CD.AYCA IgG may be a potential marker for the early diagnosis of CD,and ASCA IgG indicates an advanced stage.The combination of ASCA,AYMA,AYCA,FI2Y,and GAB improves early diagnostic accuracy of CD. 关 键 词：Crohn's disease early diagnosis serological markers AYCA ASCA
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