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Melanocortin 3,5 receptors immunohistochemical expression in colonic mucosa of inflammatory bowel disease patients:A matter of disease activity?

查看全文 作　　者：Antonietta Gerarda [1]Gravina;Iacopo [2]Panarese;Maria Consiglia [3]Trotta;Michele D'[3]Amico;Raffaele [1]Pellegrino;Franca [2]Ferraraccio;Marilena [3]Galdiero;Roberto [4]Alfano;Paolo [5]Grieco;Alessandro [1]Federico 高影响力作者 机构地区：[1]Hepatogastroenterology Division,Department of Precision Medicine,University of Campania Luigi Vanvitelli,Naples 80138,Italy;[2]Pathology Division,Department of Mental and Physical Health and Preventive Medicine,University of Campania Luigi Vanvitelli,Naples 80138,Italy;[3]Department of Experimental Medicine,Division of Pharmacology,University of Campania Luigi Vanvitelli,Naples 80138,Italy;[4]Department of Advanced Medical and Surgical Sciences(DAMSS),University of Campania Luigi Vanvitelli,Naples 80138,Italy;[5]Department of Pharmacy,University of Naples Federico II,Naples 80131,Italy高影响力机构 出　　处：《World Journal of Gastroenterology》索引2024年第30卷第9期,共11页高影响力期刊 基　　金：The study was conducted in accordance with the Declaration of Helsinki and approved by the Ethics Committee of University of Campania Luigi Vanvitelli(Protocol code 795 on December 23,2019). 摘　　要：BACKGROUND Melanocortin 3 and 5 receptors(i.e.,MC3R and MC5R)belong to the melanocortin family.However,data regarding their role in inflammatory bowel diseases(IBD)are currently unavailable.AIM This study aims to ascertain their expression profiles in the colonic mucosa of Crohn’s disease(CD)and ulcerative colitis(UC),aligning them with IBD disease endoscopic and histologic activity.METHODS Colonic mucosal biopsies from CD/UC patients were sampled,and immunohisto-chemical analyses were conducted to evaluate the expression of MC3R and MC5R.Colonic sampling was performed on both traits with endoscopic scores(Mayo endoscopic score and CD endoscopic index of severity)consistent with inflamed mucosa and not consistent with disease activity(i.e.,normal appearing mucosa).RESULTS In both CD and UC inflamed mucosa,MC3R(CD:+7.7 fold vs normal mucosa,P<0.01;UC:+12 fold vs normal mucosa,P<0.01)and MC5R(CD:+5.5 fold vs normal mucosa,P<0.01;UC:+8.1 fold vs normal mucosa,P<0.01)were significantly more expressed compared to normal mucosa.CONCLUSION MC3R and MC5R are expressed in the colon of IBD patients.Furthermore,expression may differ according to disease endoscopic activity,with a higher degree of expression in the traits affected by disease activity in both CD and UC,suggesting a potential use of these receptors in IBD pharmacology. 关 键 词：Melanocortin 3 receptor Melanocortin 5 receptor Ulcerative colitis Crohn's disease Inflammatory bowel disease
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