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Boosted sustained-release with iron-based MOF-derived mesoporouscarbon-spheres as a nitroimidazole drugs carrier

查看全文 作　　者：Danping [1]Wu;Jiaying [1]Zou;Junyi [2]Chen;Yan [3]Li;Na [3]Ma;Wei [1]Dai 高影响力作者 机构地区：[1]College of Chemistry and Materials Science,Zhejiang Normal University,Jinhua,321004,China;[2]College of Life Sciences,Zhejiang Normal University,Jinhua,321004,China;[3]College of Geography and Environmental Sciences,Zhejiang Normal University,Jinhua,321004,China高影响力机构 出　　处：《Particuology》索引2024年第86卷第3期,共12页高影响力期刊 基　　金：the National Natural Science Foundation of China(grant No.22178325). 摘　　要：Metal-organic framework(MoF)with a buildable internal structure has aroused great interest focus as self-sacrificing precursors of porous carbon(PC).However,as a drug carrier,the MOF-derived PC developed thus far are generally composed of irregular powder shape due to their crystalline nature,which consequently causing the cerebral infarction,cerebral thrombosis,and other blood diseases.In this article,we propose a novel approach to constructing amorphous carbon microspheres(AcMs)by dis-torting the topological network through hydrothermal treatment precursors of MIL-101(Fe).Then,a distinctive MIL-101(Fe)-derived spherical porous carbons(MSPC)is achieved through high temperature calcination toward ACMs.Effects of the glucose initial concentration and hydrothermal treatment time on the sphericity of the as-prepared mesoporous MsPC were investigated in depth.And the loading capacities and sustained-release performances of nitroimidazole drugs over MsPC through simulation internal environment of human body at different pH values was systematically evaluated.The nitro-imidazole drugs loading rate and release time of MsPC are 10% and 17 h under preferred process.Furthermore,the MSPC exhibited very low toxicity on Hela cells and 293T cells at the concentrations tested(10-800μg mL^(-1)).This study,therefore,supports the potential of the mesoporous carbon spheres as a carrierfor nitroimidazole drug delivery. 关 键 词：ORNIDAZOLE METRONIDAZOLE Carbon spheres Sustained-release performance Biocompatibility
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