Intratumoural microbiota:a new frontier in cancer development and therapy

查看全文 作　　者：Yaqi [1,2,3]Cao;Hui [1,2,3]Xia;Xueyun [1,2,3]Tan;Chunwei [4]Shi;Yanling [1]Ma;Daquan [1]Meng;Mengmeng [1]Zhou;Zhilei [1]Lv;Sufei [1,2,3]Wang;Yang [1,2,3]Jin

机构地区：[1]Department of Respiratory and Critical Care Medicine,Hubei Province Clinical Research Center for Major Respiratory Diseases,Key Laboratory of Respiratory Diseases of National Health Commission,State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430022,China;[2]Hubei Province Engineering Research Center for Tumour-Targeted Biochemotherapy,MOE Key Laboratory of Biological Targeted Therapy,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430022,China;[3]Hubei Province Key Laboratory of Biological Targeted Therapy,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430022,China;[4]Department of Pathogen Biology,School of Basic Medicine,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430022,China

出　　处：《Signal Transduction and Targeted Therapy》索引2024年第9卷第2期,共24页

基　　金：supported by the National Natural Science Foundation of China(No.82330003,No.82070099,No.82102496,No.82001988);National Science and Technology Major Project of the Ministry of Science and Technology of China(2022YFF1203300);Major Project of the Department of Science and Technology of Hubei(2022BCA016);Hubei Key Laboratory of Biological Targeted Therapy(2022swbx009). 摘　　要：Human microorganisms,including bacteria,fungi,and viruses,play key roles in several physiological and pathological processes.Some studies discovered that tumour tissues once considered sterile actually host a variety of microorganisms,which have been confirmed to be closely related to oncogenesis.The concept of intratumoural microbiota was subsequently proposed.Microbiota could colonise tumour tissues through mucosal destruction,adjacent tissue migration,and hematogenic invasion and affect the biological behaviour of tumours as an important part of the tumour microenvironment.Mechanistic studies have demonstrated that intratumoural microbiota potentially promote the initiation and progression of tumours by inducing genomic instability and mutations,affecting epigenetic modifications,promoting inflammation response,avoiding immune destruction,regulating metabolism,and activating invasion and metastasis.Since more comprehensive and profound insights about intratumoral microbiota are continuously emerging,new methods for the early diagnosis and prognostic assessment of cancer patients have been under examination.In addition,interventions based on intratumoural microbiota show great potential to open a new chapter in antitumour therapy,especially immunotherapy,although there are some inevitable challenges.Here,we aim to provide an extensive review of the concept,development history,potential sources,heterogeneity,and carcinogenic mechanisms of intratumoural microorganisms,explore the potential role of microorganisms in tumour prognosis,and discuss current antitumour treatment regimens that target intratumoural microorganisms and the research prospects and limitations in this field. 关键词：TUMOUR INVASION metabolism

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Intratumoural microbiota:a new frontier in cancer development and therapy

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