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Comparison of patients with hepatitis B virus-associated hepatocellular carcinoma:Data from two hospitals from Turkey and China

查看全文 作　　者：Brian [1]I.Carr;Fajuan [2]Rui;Volkan [1]Ince;Sezai [1]Yilmaz;Xinya [3]Zhao;Yuemin [4]Feng;Jie [5]Li 高影响力作者 机构地区：[1]Liver Transplantation Institute,Inonu University,Malatya,Turkey;[2]Department of Infectious Diseases,Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine,Nanjing,Jiangsu,China;[3]Department of Radiology,Shandong Provincial Hospital Affiliated to Shandong University,Jinan,Shandong,China;[4]Department of Gastroenterology,Shandong Provincial Hospital Affiliated to Shandong University,Jinan,Shandong,China;[5]Department of Infectious Diseases,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing,Jiangsu,China高影响力机构 出　　处：《Portal Hypertension & Cirrhosis》索引2023年第2卷第4期,共6页高影响力期刊 基　　金：NIH,Grant/Award Number:CA 82723;National Natural Science Fund,Grant/Award Numbers:81970545,82170609;Natural Science Foundation of Shandong Province,Grant/Award Number:ZR2020KH006;Nanjing Medical Science and Technique Development Foundation,Grant/Award Number:YKK20058;Natural Science Foundation of Jiangsu Province,Grant/Award Number:BK20231118。 摘　　要：Aims:There are many studies on the incidence of hepatitis B virus(HBV)-associated hepatocellular carcinoma(HCC),but very little is known about the HCC features in different populations.The study aimed to compare characteristics in two cohorts of patients with HBV-associated hepatocellular carcinoma from Turkey and China.Methods:Data on patients with HBV-associated HCC diagnosed by imaging or liver biopsy were retrospectively collected from Shandong Provincial Hospital(n=578)and Inonu University Hospital(n=359)between January 2002 and December 2020,and the liver function and HCC characteristics were compared.Continuous variables were compared using Student's t-test or Mann-Whitney U test and categorical variables were compared using the χ^(2) test or Fisher's exact test.Results:The patients in the Turkish cohort had significantly worse Child-Pugh scores(Child-Pugh A:38.3%vs.87.9%;Child-Pugh B:40.3%vs.11.1%;Child-Pugh C:21.4%vs.1.0%;p<0.001)and significantly higher levels of aspartate aminotransferase(66.5[38.0−126.0]vs.36.0[27.0-50.0]IU/L;p<0.001),alanine aminotransferase(47.5[30.0−87.3]vs.33.0[24.0−45.0]IU/L;p<0.001),total bilirubin(20.8[13.7−39.3]vs.17.9[13.8−24.0]mg/dL;p<0.001),and lower albumin levels(32.0[26.0-39.0]vs.40.0[36.1-43.8]g/L;p<0.001)than patients in Chinese cohort.The tumor characteristics showed the Barcelona Clinic Liver Cancer(BCLC)score(BCLC 1:5.1%vs.71.8%;BCLC 2:48.7%vs.24.4%;BCLC 3:24.4%vs.3.8%;BCLC 4:21.8%vs.0;all p<0.001),maximum tumor diameter(5.0[3.0-9.0]vs.3.5[2.5−6.0]cm;p<0.001),alpha-fetoprotein values(27.7 vs.13.2 ng/mL;p<0.001),and percentage of patients with portal vein tumor thrombus(33%vs.6.1%;p<0.001)were all significantly worse in the Turkish cohort compared with Chinese cohort.Conclusions:HBV-associated HCC from the Turkish cohort had worse liver function and more aggressive clinical characteristics than patients from the Chinese cohort. 关 键 词：China Hepatocellular Carcinoma TURKEY
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