Intelligent tunable CAR-T cell therapy leads the new trend

查看全文 作　　者：Jiayi [1]Cheng;Mingyao [1]Liu;Jiqin [1]Zhang

机构地区：[1]Shanghai Frontiers Science Center of Genome Editing and Cell Therapy,Shanghai Key Laboratory of Regulatory Biology,Institute of Biomedical Sciences and School of Life Sciences,East China Normal University,Shanghai,China

出　　处：《Synthetic and Systems Biotechnology》索引2023年第8卷第4期,共4页

基　　金：supported by the National Key R&D Program of China(2019YFA0802802);the National Natural Science Foundation of China(81772622). 摘　　要：Adoptive transfer of T cells engineered with chimeric antigen receptor(CAR)has been proved to have robust anti-tumor effects against hematological malignancies.However,problems about safety and efficacy,such as cytokine release syndrome(CRS),T cell exhaustion and antigen escape are still raised when patients are treated with CAR-T cells.Moreover,CAR-T therapy has limited applications in treating solid tumors,owing to inefficient infiltration and poor functional persistence of CAR-T cells and diverse immunosuppression in tumor microenvironment.In order to overcome these limitations and broad its applications,multiple controllable CAR-T technologies were exploited.In this article,we review the designs of intelligent controlled CAR-T technologies and the innovations that they bring about in recent years. 关键词：Chimeric antigen receptor T Tumor Safety and efficacy On and off systems Autologous universal system Synthetic notch system

相关文献

参考文献（50）
引证文献（0）
耦合文献（33）

参考文献(50)

耦合文献(33)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Intelligent tunable CAR-T cell therapy leads the new trend

参考文献(50)

耦合文献(33)

用户提示