Immunomodulatory effects and mechanisms of plant alkaloid tetrandrine in autoimmune diseases

查看全文 作　　者：LAI Jenn-HaungRheumatology/Immunology and Allergy, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, China

出　　处：《Acta Pharmacologica Sinica》索引2002年第23卷第12期,共9页

基　　金：Project supported by National Health Research Institutes,Taiwan,China.(NHRI-GT-EX89B915C)and Tri-Service General Hospital(TSGH-C91-13). 摘　　要：Autoimmune diseases characterized by activation of immune effector cells and damage of target organs are currently treated with a combination of several disease-modifying antirheumatic gruge(DMARDs) that preserve different immunomodulatory mechanisms.such a combination treatment strategy not only provides synergistic effects but also reduces side effects from individual drug.Tetrandring(Tet),purified from a creeper Stephania tetrandra S Moore,is a bis-benszylisoquinoline alkaloid and has been used to treat patients with silicosis,autoimmune disorders,and hypertension in China's Mainland for decades.The accumulated studies both in vitro and in vivo reveal that Tet preserves a wide variety of immunosuppressive effects.Importantly,the Tet-mediated immunosuppressive mechanisms are evidently different from some known DMARDs.The synergistic effects have also been demonstrated between Tet and othe DMARDs like FK506 and cyclosporin.These results highlight Tet a very potential candidate to be considered as one of DMARDs in the treatment of autoimmune diseases,especially rheumatoid arthritis.This review summarizes evidence-based in vivo and in vitro studies on this potential Chinese immunosuppressive herb. 关键词：粉防己碱 T-淋巴细胞自身免疫性疾病生物碱

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Immunomodulatory effects and mechanisms of plant alkaloid tetrandrine in autoimmune diseases

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