Effects of organophosphate,carbamate and pyrethroid insecticides and their mixtures on neuromuscular junction transmission

查看全文 作　　者：[1]HeFS;[2]XiaoC 机构地区：[1]NationalInstituteofOccupationalHealthandPoisonControl,ChineseCenterforDiseaseControlandPrevention,Beijing100050,China;[2]NationalInstituteofOccupationalHealthandPoisonControl,Chines 出　　处：《中国药理学与毒理学杂志》索引2002年第16卷第6期,共2页 摘　　要：To investigate the effects of organophosphorus (OP),carbamate (Carb),pyrehroid (Pyr) insecticides and their mixtures on neuromuscular junction transmission (NMJT),dimethoate(D) and phoxim(P),methomyl(M),and fenvalerate(F) were selected.Rats were intraperitoneally intoxicated by D,P,M,F,D+M,D+F,P+M,or P+F with the dosage of each LD50 respectively.The function of the NMJT was assessed with the mean consecutive differences (MCD) of the latencies of single fiber action potentials detected by stimulation single fiber electromyography(SSFEMG) at the stimulus frequency of 20 Hz.The SSFEMG was also applied to detect the function of NMJT in 40 patients with OPs and their mixtures poisoning in this study.The results showed that (1)the myasthenia occurred only in rats with OPs and their mixtures poisoning,but not in F,M intoxicated rats.The increase of MCD shown by SSFEMG and induced by OP and their mixtures indicating a post-synaptic block was well correlated with the occurrence of myasthenia both in rats and patients(P<0.001);(2)the increase of MCD in rats of OP poisoning was significant in comparison with the control and F,M intoxicated rats;but was not significantly different from those in rats intoxicated by OP mixtures;(3)the MCDs were significantly increased in IMS patients of both acute OP poisoning and OP mixtures poisoning,but showing no significant difference between the two groups of patients.It is concluded that OP is the only responsible agent for the dysfunction of neuromuscular transmission induced by single OP and OP mixture insecticides which could be sensitively detected by SSFEMG. 关 键 词：有机磷 福美铁 拟除虫菊酯 神经肌肉连接点传递