Toxicological study of lufironil in rats and dogs

查看全文 作　　者：[1]ZhouYP;[2]ChenSY 机构地区：[1]CenterofDrugSafetyAssessment,HubeiPharmaceuticalIndustryResearchInstitute,Wuhan430061,China;[2]CenterofDrugSafetyAssessment,HubeiPharmaceuticalIndustryResearchInstitute,Wuhan430061,Chi 出　　处：《中国药理学与毒理学杂志》索引2002年第16卷第6期,共1页 摘　　要：The aim of this study is to verify the toxicity of lufironil(LF),a competitive inhibitor of prolyl hydroxylase by long term administration in animals.SD rats and Beagle dogs were administered orally with LF for 6 months.The daily dose were 0.05,0.35,2.5mg·kg^-1 and 0.05,0.15,0.45mg·kg^-1,respectively.The recovery after stopping treatments were observed for 1 month.Hydroxyproline(Hyp) assay in serum and tissues,such as liver,kidney,lung and skin were made besides routine examinations of growth rates,food consumption,hematology,clinical chemistry and histology.The results showed that LF reduced total protein and Alb in serum,increased BUN and the weight indexes of liver,kidney and lung in the rats at the highest dose.Hykp decreased only in serum and liver.No other significant changes were seen.All the tested parameters remained normal in the dogs.It is concluded that LF is a safe drug with high selectivity on prolyl hydroxylase and its toxicity occurs only at extremely high dosage and is reversible. 关 键 词：毒理学 动物实验 lufironil