Ohmefentanyl stereoisomers induce changes of CREB phosphorylation in hippocampus of mice in conditioned place preference paradigm

查看全文 作　　者：[1]CANGAO;[2]LIWEICHEN;等

机构地区：[1]ResearchCenterforBiochemistryandMolecularBiology,XuzhouMedicalCollege,Xuzhou,Jangsu221002,China;[2]SecondDepartmetofPharmacology,ShanghaiInstituteofMateriaMedica,ShanghaiInstitutesfor

出　　处：《Cell Research》索引2003年第13卷第1期,共6页

摘　　要：The present study was designed to determine the changes of phosphorylation of cAMP- response ele-ment binding protein (CREB) in hippocampus induced by ohmefentanyl stereoisomers (F9202 and F9204)in conditioned place preference (CPP) paradigm. The results showed that mice receiving F9202 and F9204displayed obvious CPP. They could all significantly stimulate CREB phosphorylation and maintained for along time without affecting total CREB protein levels. The effect of F9204 was similar to morphine whicheffect was more potent and longer than F9202. We also examined the effects of ketamine, a noncompetitiveN-mthyl-D-aspartate receptor (NR) antagonist, on morphine-, F9202- and F9204- induced CPP and phos-phorylation of CREB in hippocampus. Ketamine could suppress not only the place preference but also thephosphorylation of CREB produced by morphine, F9202 and F9204. These findings suggest that alterationsin the phosphorylation of CREB be relevant to opiates signaling and the development of opiates dependence.NR antagonists may interfere with opiates dependence and may have potential therapeutic implications. 关键词：小鼠条件性地点偏好范式海马羟甲芬太尼 CREB磷酸化诱导变化麻醉剂依赖机制

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Ohmefentanyl stereoisomers induce changes of CREB phosphorylation in hippocampus of mice in conditioned place preference paradigm

参考文献(28)

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耦合文献(15)

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