Advances in studies on hepatic stem cells

查看全文 作　　者：HE Zuping, TANG Yuefeng, LIU Yabing and FENG Meifu(State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China)

出　　处：《Progress in Natural Science:Materials International》索引2003年第13卷第3期,共7页

基　　金：Supported by National 863 Program(Grant No.2001AA216051)and Natural Science Foundation of Beijing(Grant No.7022023) 摘　　要：The question whether hepatic stem cells exist or not has been debated for several decades. Current researches confirm that there are hepatic stem cells in the liver. Oval cells, putative bipotential hepatic stem cells, are probably located within canals of Hering, portal tracts or branches of biliary trees. Bone marrow is a potential source of oval cells, indicating that there exists a close relationship between liver and hematopoiesis in adulthood. Hepatic stem cells are able to proliferate in vitro and can be induced to differentiate into hepatocytes. This will provide a promising approach of cell transplantation, tissue engineering and gene therapy for liver diseases. In this review, the evidence of their presence, origin, identification, proliferation in vitro, differentiation by induction, application prospects of hepatic stem cells and future directions for the field are discussed. 关键词：肝干细胞体外增生细胞移植人工肝基因治疗

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Advances in studies on hepatic stem cells

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