A Genome Sequence of Novel SARS-CoV Isolates: the Genotype, GD-Ins29, Leads to a Hypothesis of Viral Transmission in South China

查看全文 作　　者：E‘[1]deQin;[2]XiongleiHe;[2]WeiTian;[2]YongLiu;[2]WeiLi;[2]JieWen;[1]BingyinSi;[2]YongwuHu;[1]WenmingPeng;[2]LinTaug;[1]TaoJiang;[2]JianpingShi;[2]JiaJia;[2]YuZhang;[2]JiaYe;Cui’[1]eWang;[2]YujunHan;[2]JingqiangWang;[1]BaochangFan;[2]QingfaWu;[1]GuohuiChang;[1]WuchunCao;[2]ZuyuanXu;[1]RuifuYang;[2]JmgWang;[1]ManYu;[2]YanLi;[2]JingXu;[2]JunZhou;[2]YajumDeng;[1]XiaoyuLi;[2]JianfeiHu;[2]CaipingWang;[2]ChunxiaYan;[2]QingrunZhang;[2]JingyueBao;[2]GuoqingLi;[2]HaiqingZhang;[2]YilinZhang;[2]HuiZhao;[2]XiaoweiZhang;[2]ShuangliLi;[2]XiaoJieCheng;[2]XiuqingZhang;[2]BinLiu;[2]ChangqingZeng;[2]HuanmingYang;[2]WeijunChen;[2]LinFang;[2]ChangfengLi;[2]MengLei;[2]DaweiLi;[2]WeiTong;[2]XiangjunTian;[2]JianWang;[2]BoZhang;[2]SonggangLi;[2]XuehaiTan;[2]SiqiLiu;[2]WeiDong;[2]JunWang;GaneKa-[2]ShuWong;[2]JunYu;[1]QingyuZhu

机构地区：[1]InstituteofMicrobiologyandEpidemiology,ChineseAcademyofMilitaryMedicalSciences,Beijing100071,China;[2]BeijingGenomicsInstitute,ChineseAcademyofSciences,Beijing101300JamesD.WatsonInstituteofGenomeSciences,ZhijiangCampus,ZhejiangUniversity,Hangzhou310008,China

出　　处：《Genomics, Proteomics & Bioinformatics》索引2003年第1卷第2期,共7页

摘　　要：We report a complete genomic sequence of rare isolates (minor genotype) of theSARS-CoV from SARS patients in Guangdong, China, where the first few casesemerged. The most striking discovery from the isolate is an extra 29-nucleotidesequence located at the nucleotide positions between 27,863 and 27,864 (referredto the complete sequence of B J01) within an overlapped region composed of BGI-PUP5 (BGI-postulated uncharacterized protein 5) and BGI-PUP6 upstream ofthe N (nucleocapsid) protein. The discovery of this minor genotype, GD-Ins29,suggests a significant genetic event and differentiates it from the previously re-ported genotype, the dominant form among all sequenced SARS-CoV isolates. A17-nt segment of this extra sequence is identical to a segment of the same size intwo human mRNA sequences that may interfere with viral genome replication andtranscription in the cytosol of the infected cells. It provides a new avenue for theexploration of the virus-host interaction in viral evolution, host pathogenesis, andvaccine development. 关键词：SARS 冠状病毒基因序列基因型

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A Genome Sequence of Novel SARS-CoV Isolates: the Genotype, GD-Ins29, Leads to a Hypothesis of Viral Transmission in South China

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