BRM-SJS INDUCES PROGRAMMED CELL DEATH IN BcaP-37 HUMAN BREAST CANCER CELLS

查看全文 作　　者：[1]刘朝阳;[2]王泽光;[2]娜迪娅;[3]Surapol;[2]赵维霞;[1]张伟

机构地区：[1]Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China;[2]Beijing Clinical Tumor Gene Research Center, Beijing 100022, China;[3]Salaya Hospital, Thailand;

出　　处：《Chinese Journal of Cancer Research》索引2003年第15卷第3期,共5页

摘　　要：Objective: To investigate the antitumor activity and the mechanism of BRM-SJS on breast cancer cells. Methods: Flow cytometry, DNA agarose gel electrophoresis and other techniques were used to study the in vitro and in vivo inhibitory effect on BcaP-37 cells by BRM-SJS. Results: BRM-SJS showed an inhibitory rate of 33.8% on in vivo transplanted tumor (P<0.05, compared with control). The flow cytometry analysis of BRM-SJS treated BcaP-37 (2.5 靘ol/L, 5 mol/L, 10 靘ol/L for 48 h and 72 h) revealed typical sub-G1 peak. The specific DNA Ladders were exhibited with BRM-SJS BcaP-37 cells treated. Conclusion: BRM-SJS has marked antitumor activity on BcaP-37 and its inhibitory effects on tumor were realized by both induction of apoptosis and necrosis of the tumor cells. 关键词：BRM-SJS 乳腺癌抗癌活性癌细胞治疗

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BRM-SJS INDUCES PROGRAMMED CELL DEATH IN BcaP-37 HUMAN BREAST CANCER CELLS

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