Spider angiomas in patients with liver cirrhosis: Role of vascular endothelial growth factor and basic fibroblast growth factor

查看全文 作　　者：Chun-Pin [1]Li;Fa-Yauh [1]Lee;Shinn-Jang [1]Hwang;Rei-Hwa [1]Lu;Wei-Ping [1]Lee;Yee [2]Chao;Sung-Sang [1]Wang;Full-Young [1]Chang;Jacqueline Whang-[3]Peng;Shou-Dong [1]Lee 机构地区：[1]Division of Gastroenterology,Department of Medicine,Taipei Veterans General Hospital and Institute of Clinical Medicine,National Yang-Ming University School of Medicine,Taipei,Taiwan,China;[2]Cancer Center,Taipei Veterans General Hospital and National Yang-Ming University School of Medicine,Taipei,Taiwan,China;[3]Cancer Research Division,National Health Research Institutes and Institute of Clinical Medicine,National Yang-Ming University School of Medicine,Taipei,Taiwan,China 出　　处：《World Journal of Gastroenterology》索引2003年第9卷第12期,共4页 基　　金：grant NSC 89-2315-B-075-004 from the National Science Council;grant VGH 90-070 from Taipei Veterans General Hospital,Taiwan 摘　　要：AIM: To investigate whether vascular endothelial growth factor (VEGF) and basic fibroblastic growth factor (bFGF) are associated wibh spider angiomas in patients wibh liver cirrhosis. METHODS: Eighty-six patients with liver cirrhosis were enrolled and the number and size of the spider angiomas were recorded. Fifty-three healthy subjects were selected as controls. Plasma levels of VEGF and bFGF were measured in both the cirrhotics and the controls. RESULTS: Plasma VEGF and bFGF were increased in cirrhotics compared with controls (122±13 vs. 71±11 pg/mL, P=0.003 for VEGF; 5.1±0.5 vs. 3.4±0.5 pg/mL, P=0.022 for bFGF). In cirrhotics, plasma VEGF and bFGF were also higher in patients with spider angiomas compared with patients without spider angiomas (185±28 vs. 90±10 pg/mL, P=-0.003 for VEGF; 6.8±1.0 vs. 4.1±0.5 pg/mL, P=0.017 for bFGF). Multivariate logistic regression showed that young age and increased plasma levels of VEGF and bFGF were the most significant predictors for the presence of spider angiomas in cirrhotic patients (odds ratio [OR]=6.64, 95% confidence interval[CI]=2.02-21.79, P=0.002; OR=4.35, 95% CI=1.35-14.01,P=0.014; OR=5.66, 95% CI=1.72-18.63, P=0.004, respectively). CONCLUSION: Plasma VEGF and bFGF are elevated inpatients with liver cirrhosis. Age as well as plasma levels of VEGF and bFGF are significant predictors for spider angiomas in cirrhotic patients. 关 键 词：血管内皮生长因子 基质纤维原细胞生长因子 肝硬化 蛛形血管瘤 作用机制