Effect of pronase as mucolytic agent on imaging quality of magnifying endoscopy

查看全文 作　　者：Gwang Ha [1]Kim;Yu Kyung [2]Cho;Jae Myung [3]Cha;Sun-Young [4]Lee;Il-Kwun [5]Chung

机构地区：[1]Department of Internal Medicine, Pusan National University School of Medicine;[2]Department of Internal Medicine, The Catholic University of Korea;[3]Department of Internal Medicine, Kyung Hee University Hospital at Gang Dong;[4]Department of Internal Medicine, Konkuk University Medical Center;[5]Department of Internal Medicine, Soonchunhyang University

出　　处：《World Journal of Gastroenterology》索引2015年第21卷第8期,共7页

基　　金：Supported by Research grant from Pharmbio Korea,Co.Ltd.,Seoul,South Korea 摘　　要：AIM:To investigate the efficacy of premedication with pronase,a proteolytic enzyme,in improving imagequality during magnifying endoscopy.METHODS:The study was of a blinded,randomized,prospective design.Patients were assigned to groups administered oral premedication of either pronase and simethicone(Group A)or simethicone alone(Group B).First,the gastric mucosal visibility grade(1-4)was determined during conventional endoscopy,and then a magnifying endoscopic examination was conducted.The quality of images obtained by magnifying endoscopy at the stomach and the esophagus was scored from1 to 3,with a lower score indicating better visibility.The endoscopist used water flushes as needed to obtain satisfactory magnifying endoscopic views.The main study outcomes were the visibility scores during magnifying endoscopy and the number of water flushes.RESULTS:A total of 144 patients were enrolled,and data from 143 patients(M:F=90:53,mean age 57.5 years)were analyzed.The visibility score was significantly higher in the stomach following premedication with pronase(73%with a score of 1 in Group A vs 49%in Group B,P<0.05),but there was no difference in the esophagus visibility scores(67%with a score of 1in Group A vs 58%in Group B).Fewer water flushes[mean 0.7±0.9 times(range:0-3 times)in Group A vs 1.9±1.5 times(range:0-6 times)in Group B,P<0.05]in the pronase premedication group did not affect the endoscopic procedure times[mean 766 s(range:647-866 s)for Group A vs 760 s(range:678-854 s)for Group B,P=0.88].The total gastric mucosal visibility score was also lower in Group A(4.9±1.5 vs 8.3±1.8in Group B,P<0.01).CONCLUSION:The addition of pronase to simethicone premedication resulted in clearer images during magnifying endoscopy and reduced the need for water flushes. 关键词：PRONASE NARROW-BAND imaging,EndoscopyImage ENHANCE

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Effect of pronase as mucolytic agent on imaging quality of magnifying endoscopy

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