Crohn's disease and risk of fracture: does thyroid disease play a role?

查看全文 作　　者：Nakechand [1]Pooran;Pankaj [1]Singh;Simmy [1]Bank

机构地区：[1]Division of Gastroenterology Albert Einstein College of Mcdicine-Long Island Jewish Medical Center New Hyde Park,New York,USA

出　　处：《World Journal of Gastroenterology》索引2003年第9卷第3期,共4页

摘　　要：AIM: To assess the role of thyroid disease as a risk for fractures in Crohn's patients.METHODS: A cross-sectional study was conducted from 1998 to 2000. The study group consisted of 210 patients with Crohn's disease. A group of 206 patients without inflammatory bowel disease served as controls. Primary outcome was thyroid disorder. Secondary outcomes included use of steroids, immunosuppressive medications, surgery and incidence of fracture.RESULTS: The prevalence of hyperthyroidism was similar in both groups. However, the prevalence of hypothyroidism was lower in Crohn's patients (3.8 % vs 8.2 %, P=0.05).Within the Crohn's group, the use of immunosuppressive agents (0 % vs11 %), steroid usage (12.5 % vs37 %), small bowel surgery (12.5 % vs 28 %) and large bowel surgery (12.5 % vs27 %) were lower in the hypothyroid subset as compared to the euthyroid subset. Seven (3.4 %) Crohn'spatients suffered fracture, all of whom were euthyroid.CONCLUSION: Thyroid disorder was not found to be associated with Crohn's disease and was not found to increase the risk for fractures. Therefore, screening for thyroid disease is not a necessary component in the management of Crohn's disease. 关键词：克隆病骨折危险因素甲状腺疾病骨密度

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Crohn's disease and risk of fracture: does thyroid disease play a role?

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