Area under the curve of methotrexate and creatinine clearance are outcome - determining factors in primary CNS lymphomas

查看全文 作　　者：[1]FerreriAJ;[1]GuerraE;[1]RegazziM;[1]PasiniF;[1]AmbrosettiA;[1]PivnikA;[1]GubkinA;[1]CalderoniA;[1]SpinaM;[1]BrandesA;[1]FerrareseF;[1]RognoneA;[1]GoviS;Dell’[1]OroS;[1]LocatelliM;[1]VillaE;[1]ReniM 机构地区：[1]Department of Radiochemotherapy,San Raffaele H Scientific Institute,Via Olgettina 60,Milan 20132,Italy 出　　处：《中国神经肿瘤杂志》索引2004年第2卷第1期,共1页 摘　　要：Although high-dose methotrexate(HD-MTX)is the most effective drug against primary CNS lymphomas(PCNSL),outcome-de-termining variables related to its administration schedule have not been defined.The impact on toxicity and outcome of the area under thecurve(AUC(MTX)),dose intensity(DI(MTX))and infusion rate(IR(MTX))of MTX and plsamatic creatinine clearance(CL(crea))was investigated in a retrospective series of 45 PCNSL patients treated with three different HD-MTX-basedcombinations.Anticon-vulsants were administered in 31 pts(69%).Age>60 years,anticonvulsant therapy,slow IR(MTX)( 关 键 词：PCNSL Area under the curve of methotrexate and creatinine clearance are outcome determining factors in primary CNS lymphomas AUC MTX CNS