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Low eradication rate of Helicobacterpyloriwith triple 7-14 days and quadriple therapy in Turkey

查看全文 作　　者：Yuksel [1]Gumurdulu;Ender [1]Serin;Birol [1]zer;Fazilet [2]Kayaselcuk;Kursat [3]Ozsahin;Arif Mansur [1]Cosar;Murat [4]Gursoy;Gurden [4]Gur;Ugur [4]Yilmaz;Sedat [4]Boyacioglu 高影响力作者 机构地区：[1]Faculty of Medicine,Baskent University,Department of Gastroenterology,Adana Teaching and Medical Research Center,Adana,Turkey;[2]Department of Pathology,Adana Teaching and Medical Research Center,Adana,Turkey;[3]Department of Family Physician,Adana Teaching and Medical Research Center,Adana,Turkey;[4]Faculty of Medicine,Baskent University,Department of Gastroenterology,Ankara Hospital,Ankara,Turkey高影响力机构 出　　处：《World Journal of Gastroenterology》索引2004年第10卷第5期,共4页高影响力期刊 摘　　要：AIM:The eradication rate of Helicobacter pylori (H pylon) shows variation among countries and regimens of treatment.We aimed to study the eradication rates of different regimens in our region and some factors affecting the rate of eradication.METHODS:One hundred and sixty-four Hpylori positivepatients (68 males, 96 females; mean age:48±12 years)with duodenal or gastric ulcer without a smoking history were included in the study. The patients were divided into three groups according to the treatment regimens. Omeprazole 20mg, clarithromycin 500mg, amoxicillin 1g were given twice daily for 1 week (Group I) and 2 weeks (Group Ⅱ).Patients in Group Ⅲ received bismuth subsitrate 300mg,tetracyline 500 mg and metronidazole 500mg four times daily in addition to Omeprazole 20mg twice daily.Two biopsies each before and after treatment were obtained from antrum and corpus, and histopathologically evaluated.Eradication was assumed to be successful if no Hpylorus was detected from four biopsy specimens taken after treatment. The effects of factors like age, sex, Hpyloridensity on antrum and corpus before treatment, the total Hpylori density, and the inflammation scores on the rate of Hpylori eradication were evaluated.RESULTS:The overall eradication rate was 42%. The rates in groups Ⅱ and Ⅲ were statistically higher than that in group I (P<0.05). The rates of eradication were 24.5%,40.7% and 61.5% in groups Ⅰ, Ⅱ and Ⅲ, respectively. The eradication rate was negatively related to either corpus Hpylori density or total Hpyloridensity (P<0.05).The median age was older in the group in which the eradication failed in comparison to that with successful eradication (55yr vs 39yr, P<0.001). No correlation between sex and Hpylori eradication was found.CONCLUSION: Our rates of eradication were significantly lower when compared to those reported in literature.We believe that advanced age and high Hpyloridensity are negative predictive factors for the rate of Hpylorieradication. 关 键 词：消化道溃疡 幽门螺杆菌 根治法 影响因素 土耳其 四联疗法
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