Effects of copper-aspirin complex on platelet-neutrophil interactions

查看全文 作　　者：Zhi-[1]qiangSHEN;[2]PengCHENt;[1]LingLI,PengCHEN;Wei-[3]pingLIU

机构地区：[1]KunmingMedicalCollege,Kunming650031,China;IPharmacologicalLaboratoriesofNaturalProducts,KunmingMedicalCallege,Kunming650031,China;[2]KunmingShenghuoPharmaceuticalLtdCo,Kunming650217;[3]~unmingInstituteofPreciousMetals,Kunming650221,China

出　　处：《Acta Pharmacologica Sinica》索引2004年第25卷第5期,共5页

基　　金：Project supported by the Natural Science Foundation of YunnanProvince; No 98C066M.2 摘　　要：AIM: To investigate the effects of copper-aspirin complex on rat thrombosis and the interaction between plateletsand neutrophils. METHODS: The model of electrically stimulated carotid artery thrombosis in Sprague Dawleyrats was used; the effects of copper-aspirin complex on rat platelet-neutrophil adhesion and platelet aggregationstimulated by activated neutrophils were observed by rosette assay and Borns method, respectively. RESULTS:Intragastric copper-aspirin complex (5, 7, and 10 mg/kg) dose-dependently prolonged the occlusion time; it signifi-cantly decreased the rosette number formed between thrombin-activated platelets and neutrophils; the 50 % ofinhibitory concentration (IC50) was (54.64.3) mol/L. Copper-aspirin complex markedly inhibited rat plateletaggregation induced by either cell free supernatant of activated neutrophils or by activated neutrophil suspension.The values of IC50 were (224.516.2) mol/L and (820.521.4) mol/L, whereas aspirin had no influence.CONCLUSION: Copper-aspirin complex inhibited platelet-neutrophil interactions through a different property fromaspirin and resulted in a more potent antithrombotic activity. 关键词：阿斯匹林铜嗜中性粒细胞血小板细胞粘附作用血栓症

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Effects of copper-aspirin complex on platelet-neutrophil interactions

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