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| 1 | The Calcineurin B-Like Calcium Sensors CBL1 and CBL9 Together with Their Interacting Protein Kinase ClPK26 Regulate the Arabidopsis NADPH Oxidase RBOHF显示文摘象反应的氧种类(ROS ) 和 Ca2+ 一样的第二个送信人的刺激特定的累积对许多在植物发信号和规定过程中央。然而,管理发信号的 Ca2+ 和 ROS 的相互的相互关系的机制开始仅仅正在出现。呼吸爆炸 oxidase 相当或相同的事物(RBOH ) 的 NADPH oxidases 家庭是当和他们的交往的 kinases (CIPK ) 的 Calcineurin 象 B 一样(CBL )Ca2+ 传感器蛋白质被显示了在表明过程的许多 Ca2+- 工作时,贡献 ROS 的产生的批评部件。在这研究,我们识别在两个都表明系统之间的直接功能的相互作用。我们报导交往 CBL 蛋白质 kinase CIPK26 明确地在酵母与 RBOHF 的 N 终端领域交往二混血儿的分析并且与在植物房间的全身的 RBOHF 蛋白质。另外,在有 CIPK26 的 CBL1 或 CBL9 的 vitro 和合作表示的 CIPK26 phosphorylates RBOHF 强烈在 HEK293T 房间由 RBOHF 提高 ROS 生产。一起,这些调查结果识别在调停 CBLCIPK 的 Ca2+ 在植物发信号并且 ROS 发信号之间的直接互联并且为 NADPH oxidase RBOHF 的 synergistic 激活提供证据由对它由 CBL1/9CIPK26 建筑群的 EF 传递和导致 Ca2+ 的 phosphorylation 直接 Ca2+ 有约束力。 | Maria Magdalena Drerup Kathrin Schlückinga Kenji Hashimoto Prabha Manishankar Leonie Steinhorst Kazuyuki Kuchitsu Jōrg Kudl | 2013 | Molecular Plant2013，6，2： | 35 |
| 2 | What have we learned about the kallikrein-kinin and renin-angiotensin systems in neurological disorders?显示文摘The kallikrein-kinin system(KKS) is an intricate endogenous pathway involved in several physiological and pathological cascades in the brain. Due to the pathological effects of kinins in blood vessels and tissues, their formation and degradation are tightly controlled. Their components have been related to several central nervous system diseases such as stroke, Alzheimer's disease, Parkinson's disease, multiple sclerosis, epilepsy and others. Bradykinin and its receptors(B1R and B2R) may have a role in the pathophysiology of certain central nervous system diseases. It has been suggested that kinin B1R is up-regulated in pathological conditions and has a neurodegenerative pattern, while kinin B2R is constitutive and can act as a neuroprotective factor in many neurological conditions. The renin angiotensin system(RAS) is an important blood pressure regulator and controls both sodium and water intake. AngⅡ is a potent vasoconstrictor molecule and angiotensin converting enzyme is the major enzyme responsible for its release. AngⅡ acts mainly on the AT1 receptor, with involvement in several systemic and neurological disorders. Brain RAS has been associated with physiological pathways, but is also associated with brain disorders. This review describes topics relating to the involvement of both systems in several forms of brain dysfunction and indicates components of the KKS and RAS that have been used as targets in several pharmacological approaches. | Maria da Graa Naffah-Mazzacoratti Telma Luciana Furtado Gouveia Priscila Santos Rodrigues Simōes Sandra Regina Perosa | 2014 | World Journal of Biological Chemistry2014，5，2： | 7 |
| 3 | The Global Stratotype Section and Point (GSSP) for the base of the Katian Stage of the Upper Ordovician Series at Black Knob Ridge, Southeastern Oklahoma, USA显示文摘 | Daniel Goldman Stephen A. Leslie Jaak Nōlvak Seth Young Stig M. Bergstroem Warren D. Huff | 2007 | Episodes2007，30，4： | 7 |
| 4 | 睾丸主要血管或睾丸网旁取精点与取精成功率不具显著相关性:以220例非梗阻性无精子症患者行传统或显微睾丸取精术为例显示文摘采用传统与显微睾丸取精术相结合方式对220例梗阻性无精症患者行精子提取术,如果传统手术方式未见精子即为阴性取精位点,然后选取2—3个阴性取精位点行显微睾丸取精术。术中通过手术显微镜评价睾丸血管系统,同时记录阳性取精位点与睾丸血供的关系。总的精子获取率为58-2%,早期应用传统手术方式精子获取率为46.8%,而后行显微睾丸取精术则精子获取率增加11.7%。故显微睾丸取精术的应用可显著增加精子获取率(P=0.017),且在睾丸网或睾丸主要血管处并不能显著增加阳性取精位点。 | J Ullrich Schwarzer Heiko Steinfatt Heiko Steinfatt Manfred Schleyer Frank M Kōhn Klaus Fiedler2, Irene von Hertwig Gottfried Krüsmann Wolfgang Würfel | 2013 | Asian Journal of Andrology2013，15，6： | 5 |
| 5 | Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer显示文摘 | Van Cutsem E Kōhne C Hitre E | | New England Journal of Medicine0，，： | 3 |
| 6 | Bound states and critical behavior of the Yukawa potential显示文摘We investigate the bound states of the Yukawa potential V(r)=-λexp(-αr)/r, using different algorithms: solving the Schrodinger equation numerically and our Monte Carlo Hamiltonian approach. There is a critical α = αC, above which no bound state exists. We study the relation between αC and A for various angular momentum quantum number l. and find in atomic units, αC(l) = λ[A1 exp(-l/B1) + A2exp(-l/B2)], with A1 = 1.020(18), B1 = 0.443(14), A2 = 0.170(17), and B2 = 2.490(180). | LI Yongyao1,LUO Xiangqian1 & Helmut Krōger2 1. Department of Physics,Sun Yat-sen University,Guangzhou 510275,China 2.Département de Physique,Université Laval,Québec G1K 7P4,Canada | 2006 | Science China(Physics,Mechanics & Astronomy)2006，49，1： | 2 |
| 7 | 金属结合剂金刚石工具在石材加工过程中的磨损(上)显示文摘讨论了金属结合剂金刚石工具在石材加工过程中的磨损机理和影响因素,并介绍了研究过程中采用的测量金刚石工具的磨损状况的两种方法。 | H.K.Tōnshoff J.Asche | 2000 | 机械工程师2000，，5： | 2 |
| 8 | Cytokinin signaling regulates pavement cell morphogenesis in Arabidopsis显示文摘难题有交错的脑叶的塑造片的 Arabidopsis 叶人行道房间(PC ) 并且缩排是一个好模型系统调查在纸巾以内协调房间极性和形状形成的机制。植物生长素被显示了 GTPase 依赖的发信号由激活 ROP 协调 interdigitation 小径。识别另外的部件或机制,我们与反常 PC 形态发生为异种屏蔽了并且发现细胞激动素发信号调整 PC interdigitation 模式。在细胞激动素累积的减小和在细胞激动素发信号的缺点(例如在 ARR7-over-expressing 线, ahk3cre1 细胞激动素受体异种,和 ahp12345 细胞激动素表明异种) 提高的 PC interdigitation,而细胞激动素的生产过剩和细胞激动素在一根 ARR20 在表示上线发信号的在激活上在整个子叶推迟了或废除 PC interdigitation。基因、生物化学的分析建议表明 ROP 在上游的行为压制交错的模式的形成的那细胞激动素。我们的结果提供控制 PC 形状的小径的新奇机械学的理解并且揭开为细胞激动素在房间形态发生发信号的一个新角色。 | Hongjiang Li Tongda Xu Deshu Lin Mingzhang Wen M ingtang Xie Jērōme Duclercq Agnieszka Bielach Jungmook Kim G Venugopala Reddy Jianru Zuo Eva Benková Jiгi Friml Hongwei Guoz Zhenbiao Yang | 2013 | Cell Research2013，23，2： | 2 |
| 9 | Sizing and Geometry Optimization of Cable-stayed Bridges 显示文摘 | Simōes LMC Negrǎo JH | 1994 | Comquters and Structures1994，52，： | 2 |
| 10 | Frequent gain of the human telomerase gene TERC at 3q26 in cervical ade- nocarcinomas 显示文摘 | Andersson S Wallin KL Hellstrōm AC | 2006 | Br J of Cancer2006，95，3： | 1 |
| 11 | High-resolution solid-state carbon-13 NMR study of chitosan and its salts with acids:conformational characterization of polymorphs and helical structures as viewed from the conformation-dependent carbon-13 chemical shifts显示文摘 | Saitō H Tabeta R Ogawa K | 1987 | Macromolecoles1987，20，： | 1 |
| 12 | Distribution of atrial natriuretic polypeptide (ANP)-containing cells in the rat heart and pulmonary vein Immunohistochemical study and radioimmunoassay显示文摘 | Hirotaka Toshimori Masamitsu Nakazato Kiyotaka Toshimori Junko Asai Shigeru Matsukura Chikayoshi ōura Hisayuki Matsuo | 1988 | Cell and Tissue Research1988，，3： | 1 |
| 13 | Finsler spaces modeled on a Minkwoski space显示文摘 | Ichijyō Y | 1976 | J Math Kyoto Univ1976，16，3： | 1 |
| 14 | One‐Dimensional 3d–3d–4f Trimetallic Assemblies Consisting of Cu<sup>II</sup><sub>2</sub>Ln<sup>III</sup> Trinuclear Complexes and Hexacyanometallate显示文摘 | TakuyaShiga AkioMishima KunihisaSugimoto Hisashiōkawa HirokiOshio MasaakiOhba | 2012 | Eur J Inorg Chem2012，，16： | 1 |
| 15 | SECI,Ba and Leadership:a Unified Model of Dynamic Knowledge Creation显示文摘 | IkujirōNonaka Ryoko Toyama Noboru Konno | 2000 | Long Range Planning2000，，33： | 1 |
| 16 | New developments using AI in fault diagnosis 显示文摘 | Frank P M Kōppen-Seliger B | 1997 | Engineering Applications of Artificial Intelligence1997，10，1： | 1 |
| 17 | Use of recombinant nucleocapsid proteins of the hantaan and nephropathia epidemica serotypes of hantaviruses as immunodiagnostic antigens显示文摘 | Zōller L Yang S Gōtt P | 1993 | Journal of Medical Virology1993，39，2： | 1 |
| 18 | Relationships between littoral diatoms and their chemical environment in northeastern German lakes and rivers显示文摘 | Schōnfelder I Gelbrecht J Schōnfelder J | 2002 | Journal of Phycology2002，38，1： | 1 |
| 19 | Terahertz semiconductor laser显示文摘 | Kōhler R Tredicucci A Beltram F | 2002 | Nature2002，417，9： | 1 |
| 20 | European Best Practice Guidelines 6-8:assessing and optimizing iron stores显示文摘 | Macdougall IC Hōrl WH Jacobs C | 2000 | Nephrol Dial Transplant2000，15，： | 1 |
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