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| 1 | The Calcineurin B-Like Calcium Sensors CBL1 and CBL9 Together with Their Interacting Protein Kinase ClPK26 Regulate the Arabidopsis NADPH Oxidase RBOHF显示文摘象反应的氧种类(ROS ) 和 Ca2+ 一样的第二个送信人的刺激特定的累积对许多在植物发信号和规定过程中央。然而,管理发信号的 Ca2+ 和 ROS 的相互的相互关系的机制开始仅仅正在出现。呼吸爆炸 oxidase 相当或相同的事物(RBOH ) 的 NADPH oxidases 家庭是当和他们的交往的 kinases (CIPK ) 的 Calcineurin 象 B 一样(CBL )Ca2+ 传感器蛋白质被显示了在表明过程的许多 Ca2+- 工作时,贡献 ROS 的产生的批评部件。在这研究,我们识别在两个都表明系统之间的直接功能的相互作用。我们报导交往 CBL 蛋白质 kinase CIPK26 明确地在酵母与 RBOHF 的 N 终端领域交往二混血儿的分析并且与在植物房间的全身的 RBOHF 蛋白质。另外,在有 CIPK26 的 CBL1 或 CBL9 的 vitro 和合作表示的 CIPK26 phosphorylates RBOHF 强烈在 HEK293T 房间由 RBOHF 提高 ROS 生产。一起,这些调查结果识别在调停 CBLCIPK 的 Ca2+ 在植物发信号并且 ROS 发信号之间的直接互联并且为 NADPH oxidase RBOHF 的 synergistic 激活提供证据由对它由 CBL1/9CIPK26 建筑群的 EF 传递和导致 Ca2+ 的 phosphorylation 直接 Ca2+ 有约束力。 | Maria Magdalena Drerup Kathrin Schlückinga Kenji Hashimoto Prabha Manishankar Leonie Steinhorst Kazuyuki Kuchitsu Jōrg Kudl | 2013 | Molecular Plant2013，6，2： | 35 |
| 2 | Calcium-dependent modulation and plasma membrane targeting of the AKT2 potassium channel by the CBL4/ ClPK6 calcium sensor/protein kinase complex显示文摘 | Katrin Held Franqois Pascaud Christian Eckert Pawel Gajdanowicz Kenji Hashimoto Claire Corratge-Faillie Jan Niklas Offenborn Benoit Lacombe Ingo Dreyer Jean-Baptiste Thibaud Jorg Kudla | 2011 | Cell Research2011，21，7： | 23 |
| 3 | Gastric cancer arising from the remnant stomach after distal gastrectomy:A review显示文摘Gastric stump carcinoma was initially reported by Balfore in 1922,and many reports of this disease have since been published. We herein review previous reports of gastric stump carcinoma with respect to epidemiology,carcinogenesis,Helicobacter pylori(H. pylori) infection,Epstein-Barr virus infection,clinicopathologic characteristics and endoscopic treatment. In particular,it is noteworthy that no prognostic differences are observed between gastric stump carcinoma and primary upper third gastric cancer. In addition,endoscopic submucosal dissection has recently been used to treat gastric stump carcinoma in the early stage. In contrast,many issues concerning gastric stump carcinoma remain to be clarified,including molecular biological characteristics and the carcinogenesis of H.pylori infection.We herein review the previous pertinent literature and summarize the characteristics of gastric stump carcinoma reported to date. | Shinsuke Takeno Tatsuya Hashimoto Kenji Maki Ryosuke Shibata Hironari Shiwaku Ippei Yamana Risako Yamashita Yuichi Yamashita | 2014 | World Journal of Gastroenterology2014，20，38： | 13 |
| 4 | On the Eve of Upgrading Antidepressants:(R)-Ketamine and Its Metabolites显示文摘Ketamine is a noncompetitive N-methyl-D-aspartate receptor(NMDAR)antagonist th has attracted widespread attention for its rapid-onset antidepressant effects,especially in individuals with treatment-resistant depression and suicidal ideation[1-3].Compared with the traditional antidepressants that take weeks,if not months,to benefit patients and are associated with a high rate of relapse,ketamine exerts its antidepressant effects | Kai Yuan Ying Han Kenji Hashimoto Lin Lu | 2016 | Neuroscience Bulletin2016，32，6： | 5 |
| 5 | Risks Associated with Misuse of Ketamine as a Rapid-Acting Antidepressant显示文摘Major depression is a serious psychiatric disorder and remains a leading cause of disability worldwide.Conventional antidepressants take at least several weeks to achieve a therapeutic response and this lag period has hindered their ability to attain beneficial effects in depressed individuals at high risk of suicide.The non-competitive Nmethyl-D-aspartate glutamate receptor antagonist ketamine has been shown to have rapid antidepressant effects in both rodents and humans.The emergence of ketamine as a fastacting antidepressant provides promising new insights into the development of a rapid treatment response in patients with clinical depression.However,its safety and toxicity remain a concern.In this review,we focus on the limitations of ketamine,including neurotoxicity,cognitive dysfunction,adverse events associated with mental status,psychotomimetic effects,cardiovascular events,and uropathic effects.Studies have shown that its safety and tolerability profiles are generally good at low doses and with short-term treatment in depressed patients.The adverse events associated with ketamine usually occur with very high doses that are administered for prolonged periods of time and can be relieved by cessation.The antidepressant actions of its two enantiomers,S-ketamine(esketamine) and R-ketamine,are also discussed.R-ketamine has greater antidepressant actions than S-ketamine,without ketamine-related sideeffects.Future treatment strategies should consider using Rketamine for the treatment of depressed patients to decrease the risk of adverse events associated with long-term ketamine use. | Weili Zhu Zengbo Ding Yinan Zhang Jie Shi Kenji Hashimoto Lin Lu | 2016 | Neuroscience Bulletin2016，32，6： | 5 |
| 6 | 精力的文学评论为执行 laparoscopic colorectal 外科采购原料显示文摘 Laparoscopic surgery for colorectal disease has become widespread as a minimally invasive treatment.This is important because the increasing availability of new devices allows us to perform procedures with a reduced length of surgery and decreased blood loss.We herein report the results of a literature review of energy sources for laparoscopic colorectal surgery,focused especially on 6 studies comparing ultrasonic coagulating shears(UCS) and other instruments.We also describe our laparoscopic dissection techniques using UCS for colorectal cancer.The short-term outcomes of surgeries using UCS and Ligasure for laparoscopiccolorectal surgery were superior to conventional electrosurgery.Some authors have reported that the length of surgery or blood loss when Ligasure was used for laparoscopic colorectal surgery is less than when UCS was used.On the other hand,a recent study demonstrated that there were no significant differences between the short-term outcomes of UCS and Ligasure for laparoscopic colorectal surgery.It is therefore suggested that the choice of technique used should be made according to the surgeon’s preference.We also describe our laparoscopic dissection techniques using UCS(Harmonic ACE) for colorectal cancer with regard to the retroperitoneum dissection,dissection technique,dissection technique around the feeding artery,and various other dissection techniques.We therefore review the outcomes of using various energy sources for laparoscopic colorectal surgery and describe our laparoscopic dissection techniques with UCS(Harmonic ACE) for colorectal cancer. | Tsukasa Hotta Katsunari Takifuji Shozo Yokoyama Kenji Matsuda Takashi Higashiguchi Toshiji Tominaga Yoshimasa Oku Takashi Watanabe Toru Nasu Tadamichi Hashimoto Koichi Tamura Junji Ieda Naoyuki Yamamoto Hiromitsu Iwamoto Hiroki Yamaue | 2012 | World Journal of Gastrointestinal Surgery2012，4，1： | 4 |
| 7 | Clinical impact of c-Met expression and its gene amplification in hepatocellular carcinoma显示文摘 | Shunsuke Kondo Hidenori Ojima Hitoshi Tsuda Jun Hashimoto Chigusa Morizane Masafumi Ikeda Hideki Ueno Kenji Tamura Kazuaki Shimada Yae Kanai Takuji Okusaka | 2013 | International Journal of Clinical Oncology2013，，2： | 2 |
| 8 | Phase I and pharmacokinetic study of nab-paclitaxel, nanoparticle albumin-bound paclitaxel, administered weekly to Japanese patients with solid tumors and metastatic breast cancer显示文摘 | Masashi Ando Kan Yonemori Noriyuki Katsumata Chikako Shimizu Taizo Hirata Harukaze Yamamoto Kenji Hashimoto Mayu Yunokawa Kenji Tamura Yasuhiro Fujiwara | 2012 | Cancer Chemotherapy and Pharmacology2012，，2： | 2 |
| 9 | Chon-dricyte apoptsis and nitric oxide production during experimentally induced osteoarthritis 显示文摘 | Kenji Takahashi David Aiel | 1998 | Arthritis Rheum1998，41，7： | 1 |
| 10 | Increased midkine levels in sera from patients with Alzheimer’s disease显示文摘 | Ragaa H.M. Salama Hisako Muramatsu Eiji Shimizu Kenji Hashimoto Shintaro Ohgake Hiroyuki Watanabe Naoya Komatsu Naoe Okamura Kaori Koike Naoyuki Shinoda Shin-ichi Okada Masaomi Iyo Takashi Muramatsu | 2005 | Progress in Neuropsychopharmacology & Biological Psychiatry2005，，4： | 1 |
| 11 | Chondrocyte apoptosis and nitric oxide production during experimentally induced osteoarthritis显示文摘 | Sanshiro Hashimoto Kenji Takahashi David Aiel | 1998 | Arthritis Rheum1998，41，7： | 1 |
| 12 | Chondrocyte apoptosis and nitric oxide production during experimentally induced osteoartbritis显示文摘 | Sanshiro Hashimoto Kenji Takahashi David Aiel | 1998 | Arthritis Rheum1998，41，7： | 1 |
| 13 | Analysis of cell characterization using cell surface markers in the dermis显示文摘 | Yuichi Hasebe Seiji Hasegawa Noriko Hashimoto Masashi Toyoda Kenji Matsumoto Akihiro Umezawa Akiko Yagami Kayoko Matsunaga Hiroshi Mizutani Satoru Nakata Hirohiko Akamatsu | 2011 | Journal of Dermatological Science2011，，2： | 1 |
| 14 | Effect of multimodal microstructure evolution on mechanical properties of Mg-Zn-Y extruded alloy显示文摘 | Yamasaki Michiaki Hashimoto Kenji Hagihara Koji | 2011 | Acta Materialia2011，59，： | 1 |
| 15 | Brain-derived neurotrophic factor as abiomarker for mood disorders: an historical overview andfuture directions 显示文摘 | Hashimoto Kenji | 2010 | Psychiatry and Clinical Neurosciences2010，64，4： | 1 |
| 16 | Matrix extracellular phosphoglycoprotein (MEPE) is highly expressed in osteocytes in human bone显示文摘 | Akihide Nampei Jun Hashimoto Kenji Hayashida Hideki Tsuboi Kenrin Shi Isamu Tsuji Hideaki Miyashita Takao Yamada Naomichi Matsukawa Masayuki Matsumoto Shigeto Morimoto Toshio Ogihara Takahiro Ochi Hideki Yoshikawa | 2004 | Journal of Bone and Mineral Metabolism2004，，3： | 1 |
| 17 | Population ageing and wellbeing: lessons from Japan's long-term care insurance policy显示文摘 | NANAKO TAMIYA HARUKO NOGUCHI AKIHIRO NISHI MICHAEL R REICH NAOKI IKEGAMI HIDEKI HASHIMOTO KENJI SHIBUYA ICHIRO KAWACHI JOHN CREIGHTON CAMPBELL | 2011 | The Lancet2011，，378： | 1 |
| 18 | SNPs in the promoter region of the osteopontin gene as a marker predicting the efficacy of interferon-based therapies in patients with chronic hepatitis C显示文摘 | Masashi Naito Atsushi Matsui Mie Inao Sumiko Nagoshi Makoto Nagano Nobuko Ito Tohru Egashira Michie Hashimoto Shunji Mishiro Satoshi Mochida Kenji Fujiwara | 2005 | Journal of Gastroenterology2005，，4： | 1 |
| 19 | The design and optimization of a series of 2-(pyridin-2-yl)-1 H -benzimidazole compounds as allosteric glucokinase activators显示文摘 | Keiji Takahashi Noriaki Hashimoto Chisato Nakama Kenji Kamata Kaori Sasaki Riki Yoshimoto Sumika Ohyama Hideka Hosaka Hiroko Maruki Yasufumi Nagata Jun-ichi Eiki Teruyuki Nishimura | 2009 | Bioorganic & Medicinal Chemistry2009，，19： | 1 |
| 20 | A new ehromone from agarwood and pyrolysis products of chromone derivatives 显示文摘 | HASHIMOTO Kenji NAAHARA Sachiko INOUE Takehisa | 1985 | Chemical and Pharmaceutical Bulletin1985，33，： | 1 |
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