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| 1 | Clinical implication of VEGF serum levels in cirrhotic patients with or without portal hypertension显示文摘INTRODUCTIONAngiogenesisorformationofnewbloodvesels,isatightlyregulatedprocesinwhichbloodveselssupplygrowingtisuewithnutrient... | Nimer Assy 1,4 , M Paizi 3,4 , D Gaitini 2, Y Baruch 1,4 and G Spira 3,4,5 | 1999 | World Journal of Gastroenterology1999，5，4： | 35 |
| 2 | OPTICAL PROPERTIES OF GeO_2 AND Ge NANOCRYSTALS显示文摘he co m pound m aterial of n m size particles Ge O2 Si O2 w as synthesied through hydrolysis of Si( O C2 H4) and Ge Cl4 . A heat treatm ent w as carried out for the sa m ples at 100 ~1200 ℃in air . Its optical property w as deter mined by U V Vis spectur m . We have found that theabsorption edge of spectru m shifted progressively to longer w avelengths . The quantu m size ef fect of nanocrystals appears because crystals gro w and energy of optical band gap reduces d ueto the influence of te m perature . By the analysis of X ray diffraction w e have observed theprocess in w hich the structure of particles changed fro m disorder into order . | Y.H.Zhou 1) ,Y.Y.Feng 2) and H.Y.Lu 2) 1)Department of Physics Nanjing Normal University, Nanjing 210097,China 2)Physics and Ch寁O P T I C A L P R O P E R T I E S O F Ge O2 A N D Ge N A N O C R Y S T A L S Y. H. Zhou1) , Y. Y. Feng2) | 1999 | Acta Metallurgica Sinica(English Letters)1999，12，5： | 22 |
| 3 | Caveolin-1 gene silencing promotes the activation of PI3K/AKT dependent on Erα36 and the transformation of MCF10A^(CE)显示文摘ERα36,a variant of estrogen receptor-α,acts as a dominant-negative factor in both estrogen-dependent and estrogen-independent transactivation signaling pathways,and is a key factor in the promotion,progression and prognosis of breast cancers.Caveolin-1,a 22-to 24-kD integral membrane protein,may function as a tumor suppressor in inhibiting of many growth-promoting signaling pathways.It was shown that downregulation of Caveolin-1 strengthens the interaction of ERα and Caveolin-1.In conclusion,Caveolin-1 gene silencing activated the PI3K/AKT signaling pathway in an ERα36-dependent way.Our finding may provide a promising therapeutic target of breast cancer. | FENG Shuang1,WANG Yang1,WANG Xi1,WANG ZhaoYi3,CUI YuYing1,LIU Jing4,ZHAO ChunHui1,JIN Mei1,2 & ZOU Wei1,2 1 College of Life Science,Liaoning Normal University,Dalian 116029,China 2 Liaoning Key Laboratory of Biotechnology and Molecular Drug R&D,Dalian 116029,China 3 Cancer Center,Creighton University,2500 California Plaza,Omaha,NE 68178,USA 4 First Clinical Hospital of Dalian Medical University,Dalian 116011,China | 2010 | Science China(Life Sciences)2010，53，5： | 16 |
| 4 | Friction Characteristics of Mechanical Seals with Laser-textured Seal Faces显示文摘Heat generated by friction between faces of mechanica l seals is a major factor that causes deterioration of the seals and shortens th eir service life. Excessive temperature rise can greatly alter the seal geometry and vaporize the sealing fluid, resulting in friction of boundary lubrication. These effects on face seals usually lead to excessive leakage and ultimately ren der the seal inoperable. In order to maintain the reliability of seals, high fri ction and unwanted wear must be avoided. Using the laser-texturing process to produce regular micro-surface structures is a fast and convenient technique compared to some more conventional etching or erosion technique currently used by the seal industry for various grooved face seals. Indeed, by using a pulse laser, better control is obtained on the geometr y, size and pore ratio of seal rings made of metallic or ceramic materials. In t his study, seal rings are made of silicon carbide and carbon. Mating faces of th e rings are polished and only silicon carbide rings are laser-textured. The las er texturing can be controlled to produce spherical pores at selected diameters, depths and pore ratio. The textured rings are then super-polished to remove th e bulges formed on the pores rims. After this process the average pore diameter, pore depth and pore ratio reach the predetermined parameter. Some untextured ri ngs are also treated to the same surface roughness and served as a reference for comparison of the textured rings. A special test rig is used to simulate a mech anical seal system and to measure the effect of the laser texturing on friction and seal performance. Tests are performed at various rotational speeds and vario us axial loads. Compared with the conventional mechanical seals, temperature rise, friction torq ue and friction coefficient of mechanical seals with laser-textured seal faces are much lower. These preliminary results show the potential of improving fricti on performance and increasing seal life with laser-textured seal faces. | YU Xin-qi 1,2, HE Song 1, CAI Ren-ling 1 (1. Research Institute of Pressure Vessel and Process Equi pment, East China University of Science and Technology, Shanghai 200237, China 2. College of Mechanical Science and Engineering, Hebei University of Science an d Technology, Shijiazhuang 050018, China) | 2002 | 厦门大学学报(自然科学版)2002，41，S1： | 9 |
| 5 | Quantum phase transition and entanglement in Li atom system显示文摘By use of the exact diagonalization method, the quantum phase transition and en- tanglement in a 6-Li atom system are studied. It is found that entanglement appears before the quantum phase transition and disappears after it in this exactly solvable quantum system. The present results show that the von Neumann entropy, as a measure of entanglement, may reveal the quantum phase transition in this model. | SI LiMing1 & HOU JiXuan2 1 Department of Electronic Engineering, School of Information Science and Technology, Beijing Institute of Technology, Beijing 100081, China 2 Laboratoire de Chimie, UMR 5182 CNRS, Ecole Normale Supérieure de Lyon, 46, Allée d’Italie, F-69364 Lyon Cedex 07, France | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，11： | 6 |
| 6 | Effects of disinhibition on spatiotemporal pattern of neuronal first recruitment in neuronal networks显示文摘The propagation of neuronal activities is a key feature to understanding information processing in networks. The analysis based on first-spikes of bursts in turn plays an important role in the research of neuronal activity propagation. Our focus here is to investigate how spatiotemporal patterns of neuronal first-spikes are affected by disinhibition. Multi-electrode arrays were used to record stimulation-evoked bursts of multiple neurons in randomly cultured neuronal networks. Both the precise timing of and the rank relationships between first-spikes were analyzed. Compared with evoked bursts in the network's native state, the precise first-spike latencies in its dis-inhibited state are more consistent and the propagation of its bursting activities is much faster. Additional points of interest are that disinhibited neuronal networks can be evoked to generate stable and distinguishable neuronal first recruitment spatiotemporal patterns specific to the stimulation site, and that the disinhibition may cause the original spatiotemporal patterns to change in a heterogeneous manner with regards to different propagation pathways. | Liangbin Pana,b,c,1, Xindong Songa,b,c,1, Guangxin Xiang a,b,c, Jing Zhua,b,c, Jing Cheng a,b,c,d,a Medical Systems Biology Research Center, Tsinghua University School of Medicine, Beijing 100084, China b Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China c National Engineering Research Center for Beijing Biochip Technology, 18 Life Science Parkway, Beijing 102206, China d State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University, Beijing 100084, China | 2009 | Progress in Natural Science:Materials International2009，19，5： | 6 |
| 7 | Enhancing disease resistances of Super Hybrid Rice with four antifungal genes显示文摘A plant expression vector harboring four antifungal genes was delivered into the embryogenic calli of ‘9311’, an indica restorer line of Super Hybrid Rice, via modified biolistic particle bombardment. Southern blot analysis indicated that in the regenerated hygromycin-resistant plants, all the four anti-fungal genes, including RCH10, RAC22, β-Glu and B-RIP, were integrated into the genome of ‘9311’, co-transmitted altogether with the marker gene hpt in a Mendelian pattern. Some transgenic R1 and R2 progenies, with all transgenes displaying a normal expression level in the Northern blot analysis, showed high resistance to Magnaporthe grisea when tested in the typical blast nurseries located in Yanxi and Sanya respectively. Furthermore, transgenic F1 plants, resulting from a cross of R2 homo-zygous lines with high resistance to rice blast with the non-transgenic male sterile line Peiai 64S, showed not only high resistance to M. grisea but also enhanced resistance to rice false smut (a disease caused by Ustilaginoidea virens) and rice kernel smut (another disease caused by Tilletia barclayana). | ZHU HuaChen1, XU XinPing1, XIAO GuoYing2,3, YUAN LongPing2 & LI BaoJian1 1 Biotechnology Research Center, Key Laboratory of Gene Engineering of Ministry of Education, Sun Yat-sen University, Guangzhou 510275, China 2 China National Hybrid Rice R&D Center, Hunan Hybrid Rice Research Center, Changsha 410125, China 3 Institute of Subtropical Agriculture, the Chinese Academy of Sciences, Changsha 410125, China | 2007 | Science China(Life Sciences)2007，50，1： | 6 |
| 8 | Agent-oriented Aid-modeling for the Distributed Activity Network | DENG Gui\|shi\+1,\ LI Wen\|lei\+1,\ O. Moeschlin\+2 1.Institute of Systems Engineering, Dalian University of Technology Dalian 116024, China 2.Department of Mathematics, Fern University in Hagen, D 58084 Germany | 2000 | Systems Science and Systems Engineering2000，10，1： | 4 |
| 9 | The influence of impurity on the critical thickness of the CeO_2 buffer layer for coated conductors显示文摘The lattice parameters, band structure, density of state and elastic constant of RE-doped CeO2 (RE=Sm, Gd, Dy), the buffer material for coated HTS conductors, are calculated using the plane-wave method with pseudopotentials based on the density functional theory (DFT) of first-principle. The rule and mechanism of the effect of rare earth impurity on the critical thickness of the CeO2 buffer layer are investigated. It is found that, in the range of the calculation, the changes of the lattice volume V and elastic constant E of CeO2 with the impurity are mainly determined by the increased electrons ne of the system. The relationship of the elastic constant E and increased electrons ne is established. It is indicated that the critical thickness of the CeO2 single buffer layer doped with Sm, Gd, and Dy may be enhanced by 22%, 43% and 33%, respectively. | PAN Min1, HUANG Zheng2, MA HuanFeng2, QIANG WeiRong2, WEI LianFu1, WANG Long2 & ZHAO Yong1,3 1 Key Laboratory of Magnetic Levitation Technologies and Maglev Trains (Ministry of Education of China), Superconductivity R&D Center (SRDC), Southwest Jiaotong University, Chengdu 610031, China 2 School of Physical Science and Technology, Southwest Jiaotong University, Chengdu 610031, China 3 Superconductivity Research Group, School of Materials Science and Engineering, University of New South Wale, Sydney, 2052 NSW, Australia | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，7： | 3 |
| 10 | Surface Activities of Calix [4]resorcinarenes Bearing Four Hydrophobic Chains and Its Solubilization for Organic Compounds显示文摘Calix resorcinarenes bearing four hydrophobic side chains ( Ar-Rn, Ar-Ph, and Ar-N) orient stably on water oil interface and show high solubilization capacities for organic compounds, such as long chain alcohols, benzene, toluene and dyes. The capacities are high even near the cmc of polyalkylated calix resorcinarenes, but the solubilities of organic compounds(solubilizates) decrease with the increase of the size of the solubilizates. Ar-R 6, with a chain length of six carbons, is the most effective among Ar-R n , Ar-Ph, and Ar-N; 11 fold mol of hexanol is dissolved in 2×10 -3 mol/L Ar-R 6. Moreover, Ar-R n bearing four alkyl side chains solubilizes the chain alcohols of the same chain length mostly. The solubilization capacities are presumably brought by inclusion in a large cavity of the polyalkylated calix resorcinarenes and by an efficient orientation of the solubilizates. | LI Bo *1 , Yoshifumi KOIDE 1 and Kunio ESUMI 21. Toyota Central R & D Labs., Inc., 41 1, Yokomichi, Nagakute, Aichi 480 1192, Japan 2. Departemnt of Applied Chemistry and Institute of Colloid and Interface Science, Science University of Tokyo | 2002 | Chemical Research in Chinese Universities2002，18，2： | 3 |
| 11 | Distortion control of conjugacies between quadratic polynomials显示文摘We use a new type of distortion control of univalent functions to give an alternative proof of Douady-Hubbard’s ray-landing theorem for quadratic Misiurewicz polynomials. The univalent maps arise from Thurston’s iterated algorithm on perturbation of such polynomials. | CUI GuiZhen 1, & TAN Lei 2 1 Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing 100190, China 2 Laboratoire de Mathmatiques, UMR du CNRS 6093, Universit d’Angers, 2 bd. Lavoisier, 49045 Angers cedex 01, France | 2010 | Science China Mathematics2010，53，3： | 3 |
| 12 | BATE curve in assessment of clinical utility of predictive biomarkers显示文摘In this paper,for time-to-event data,we propose a new statistical framework for casual inference in evaluating clinical utility of predictive biomarkers and in selecting an optimal treatment for a particular patient.This new casual framework is based on a new concept,called Biomarker Adjusted Treatment Effect (BATE) curve.The BATE curve can be used for assessing clinical utility of a predictive biomarker,for designing a subsequent confirmation trial,and for guiding clinical practice.We then propose semi-parametric methods for estimating the BATE curves of biomarkers and establish asymptotic results of the proposed estimators for the BATE curves.We also conduct extensive simulation studies to evaluate finite-sample properties of the proposed estimation methods.Finally,we illustrate the application of the proposed method in a real-world data set. | ZHOU XiaoHua 1,2,3,& MA YunBei 4,5 1 Northwest HSR&D Center of Excellence,VA Puget Sound Health Care System,Seattle,WA 98198,USA 2 Department of Biostatistics,University of Washington,Seattle,WA 98198,USA 3 Beijing International Center for Mathematical Research,Peking University,Beijing 100871,China 4 Department of Operations Research and Financial Engineering,Princeton University,Princeton,NJ 08540,USA 5 School of Statisitcs,Southwest University of Finance and Economics,Chengdu 611130,China | 2012 | Science China Mathematics2012，55，8： | 2 |
| 13 | Cesium accumulation by bacterium Thermus sp. TibetanG7:hints for biomineralization of cesium-bearing geyserite in hot springs in Tibet,China显示文摘The bacterium Thermus sp. TibetanG7, isolated from hot springs in Tibet, China, was examined for the ability to accumulate cesium from solutions. Environmental conditions were simulated and the effects of pH, K+, Na+ and K+-regimes were then studied to determine the possible role of the bacterium in the formation of cesium-bearing geyserite around these hot springs. In despite of the inhibition of K+ and Na+, the bacterium Thermus sp. TibetanG7 revealed noticeable accumulation of cesium from solutions, with maximum accumulations of 53.49 and 40.41 μmol Cesium/g cell dry weight in Na+ and K+ inhibition experiments, respectively. The accumulation of cesium by this microorganism is rapid, with 40%―50% accumulated within the first 5 min. K+-deficient cells showed a much higher capacity of cesium accu- mulation compared with K+-sufficient cells. It is evident that the bacteria within the genus thermus play a significant role in the cesium assembly. The formation of cesium-bearing geyserite is also considered. | WANG HaiLei1,2,3, ZHENG MianPing1,2,3 & HUANG XiaoXing4 1 Institute of Mineral Resources, Chinese Academy of Geological Sciences (CAGS), Beijing 100037, China 2 R&D Center for Saline Lake and Epithermal Deposits, CAGS, Beijing 100037, China 3 Open Laboratory of Saline Lake Resourses and Environment, CAGS, Beijing 100037, China 4 Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100081, China | 2007 | Chinese Science Bulletin2007，52，19： | 2 |
| 14 | Licensing of university innovations: The role of a technology transfer office 显示文摘 | MACHO - STADLER 1 P? REZ - CASTRILLO D VEUGELERS R | 2007 | International Journal of Industrial Organization2007，25，： | 1 |
| 15 | Tumor necrosis factor induction by an aqueous phenol-extracted lipopolysac-charide complex from Bacteroides species 显示文摘 | Delahooke D M Barclay G R Poxton 1 R | 1995 | Infect Immun1995，63，3： | 1 |
| 16 | Cardiac re-modeling and failure : from molecules to man ( Part 1 ) 显示文摘 | Fedak 1' W Verma S Weisel R D | 2005 | Cardiovasc: Pathol2005，14，： | 1 |
| 17 | Electrical triggering of metal-insulator transition in nanoscale vanadium oxide junctions显示文摘 | Ruzmeto 1 D Gnpalakrisbnan G Deng J D | 2009 | Journal of Applied Physics2009，106，08： | 1 |
| 18 | 显示文摘 | Samain D Descoins C A short stereo - selective synthesis of E E - 8 10 -dode cadien - 1 - ol the sex pheromone of the codling moth Laspeyresia pomoneUa L | 1978 | Synthesis1978，，5： | 1 |
| 19 | Disappearing stem cells, disappearing seience显示文摘 | Weissman 1 L Baltimore D | 2001 | Science2001，292，5517： | 1 |
| 20 | Mechani- cal Properties of a Material at Ultrahigh Strain Rates In-duced by a Laser Shock Wave 显示文摘 | BATANI D VOVCHENKO V 1 KANEL G 1 | 2003 | Doklady Physics2003，48，3： | 1 |
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